ArticlePloS one2012
Factors that influence parental attitudes toward enrollment in type 1 diabetes trials.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Motivations of children and their parents to participate in drug research: a systematic review.European journal of pediatrics · 2016Pooled it
- Recruitment Into a Pediatric Continuous Glucose Monitoring RCT.Journal of diabetes science and technology · 2017Trial
- Exploring the Motivational Drivers of Young Adults with Diabetes for Participation in Kidney Research.Journal of patient experience · 2022Article
- Enroller Experience and Parental Familiarity of Disease Influence Participation in a Pediatric Trial.The western journal of emergency medicine · 2021Article
- Utilizing Community Engagement Studios to inform patient experience in a multicenter randomized control trial.International journal of pediatric otorhinolaryngology · 2020Article
- Recruiting young pre-symptomatic children for a clinical trial in type 1 diabetes: Insights from the Fr1da insulin intervention study.Contemporary clinical trials communications · 2018Article
- Barriers and facilitators to clinical trial participation among parents of children with pediatric neuromuscular disorders.Clinical trials (London, England) · 2018Article
- Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative.Contemporary clinical trials communications · 2018Article
- Back to school: challenges and rewards of engaging young children in scientific research.Archives of disease in childhood · 2016Article
- Development and Psychometric Evaluation of the HPV Clinical Trial Survey for Parents (CTSP-HPV) Using Traditional Survey Development Methods and Community Engagement Principles.Clinical and translational science · 2015Article
- Clinical trials involving cats: what factors affect owner participation?Journal of feline medicine and surgery · 2014Article
- Motivations of Patients with Diabetes to Participate in Research.AJOB empirical bioethics · 2014Article
- Parent Perceptions of and Preferences for Participation in Child Health Research: Results from a Pediatric Practice-Based Research Network.Journal of the American Board of Family Medicine : JABFMArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
aimsTo assess parental attitudes towards type 1 diabetes clinical trials (T1DCTs) and factors that impact willingness to enroll their children with and without diabetes.
methodsA cross-sectional survey of parents of children with type 1 diabetes was administered at an academic clinic and a diabetes educational event.
resultsSurvey response rate was 36%. Of 166 participating parents, 76% were aware of T1DCTs. More parents reported willingness to enroll children with diabetes (47%) than unaffected children (36%). Only 18% recalled being asked to enroll their children, and of these, 60% agreed to enroll at least some of those times. Less than 30% were comfortable with placebos. Factors predicting willingness to enroll children with diabetes included healthcare provider trust, comfort with consent by proxy, low fear of child being a "guinea pig," and comfort with placebo. Factors predicting willingness to enroll unaffected children were provider trust, comfort with consent by proxy, comfort with placebo, and perceived ease of understanding T1DCT information.
conclusionsParents report moderate willingness to enroll children in T1DCTs. Willingness is diminished by common trial methodologies. Although most parents recalled receiving trial-related information, significantly fewer recalled being asked to participate. Efforts to optimize effective communication around identified areas of parental concern may increase T1DCT participation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.