ArticlePloS one2012
Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 77 citations in OpenAlex.
- Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives.Molecules (Basel, Switzerland) · 2025Review
- Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications.Molecular nutrition & food research · 2025Review
- Polyherbal Formulation as a Therapeutic Strategy for Lung Cancer: Phytochemical Profiling, Molecular Docking, and Pharmacological Evaluation.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Potential Distribution Prediction ofEcology and evolution · 2025Article
- Triphala's characteristics and potential therapeutic uses in modern health.International journal of physiology, pathophysiology and pharmacology · 2025Review
- Ayurvedic Drug Triphala in Combination with Providone Iodine Mitigates Radiation-Induced Mucositis in Head and Neck Cancer Patients without Affecting the Tumor Response.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer.British journal of cancer · 2022Article
- Triphala extract negates arecoline-induced senescence in oral mucosal epithelial cells in vitro.Saudi journal of biological sciences · 2021Article
- Assessment of the Cytotoxic Activity of Triphala: A Semisolid Traditional Formulation on HepGBioMed research international · 2021Article
- Hepatoprotective Effects of Different Extracts FromFrontiers in pharmacology · 2021Article
- Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice.Arthritis research & therapy · 2020Article
- Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis.Biomolecules · 2020Article
- Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala.Antioxidants (Basel, Switzerland) · 2020Review
- Triphala inhibits alpha-synuclein fibrillization and their interaction study by NMR provides insights into the self-association of the protein.RSC advances · 2019Article
- Intraradicular Smear Removal Efficacy of Triphala as a Final Rinse Solution in Curved Canals: A Scanning Electron Microscope Study.Journal of pharmacy & bioallied sciences · 2019Article
- Nutraceutical effects ofAging · 2019Article
- Chebulinic acid derived from triphala is a promising antitumour agent in human colorectal carcinoma cell lines.BMC complementary and alternative medicine · 2018Article
- An Integrated Study on the Antitumor Effect and Mechanism of Triphala Against Gynecological Cancers Based on Network Pharmacological Prediction and In Vitro Experimental Validation.Integrative cancer therapies · 2018Article
- Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders.Chinese medicine · 2018Review
- Chebulinic acid inhibits smooth muscle cell migration by suppressing PDGF-Rβ phosphorylation and inhibiting matrix metalloproteinase-2 expression.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Triphala churna (THL) is a combination of three fruits that has been used for many years in India for the treatment of various diseases. There are now reports which indicate that THL can inhibit growth of malignant tumors in animals. However, the mechanisms by which THL mediates its anti-tumor actions are still being explored. Because vascular endothelial growth factor-A (VEGF) induced angiogenesis plays a critical role in the pathogenesis of cancer, we therefore investigated whether tumor inhibitory effects of THL or its active constituents are through suppression of VEGF actions. We herein report that THL and chebulinic (CI) present in THL can significantly and specifically inhibit VEGF induced angiogenesis by suppressing VEGF receptor-2 (VEGFR-2) phosphorylation. These results are of clinical significance as these inexpensive and non-toxic natural products can be used for the prevention and treatment of diseases where VEGF induced angiogenesis has an important role.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.