ArticlePloS one2012
A toolbox for tuberculosis diagnosis: an Indian multicentric study (2006-2008): microbiological results.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of reported cost for smear and culture tests during multidrug-resistant tuberculosis treatment.PloS one · 2013Pooled it
- Trial
- The Effect of Empiric Initiation of Treatment on Outcomes Among Patients Presenting With Extrapulmonary Mycobacterium Tuberculosis Infection in a Community Hospital Setting.Journal of community hospital internal medicine perspectives · 2026Article
- A Dual Marker for Monitoring MDR-TB Treatment: Host-Derived miRNAs andFrontiers in immunology · 2021Article
- Culture positivity of smear negative pulmonary and extrapulmonary tuberculosis- A study from North Kerala, India.Journal of family medicine and primary care · 2019Article
- Tuberculosis Biomarkers: From Diagnosis to Protection.Infectious disease reports · 2016Review
- Incidence and Predictors of Tuberculosis among HIV Positive Children at University of Gondar Referral Hospital, Northwest Ethiopia: A Retrospective Follow-Up Study.International scholarly research notices · 2015Article
- Article
- Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease.PloS one · 2013Article
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26 authors.
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Abstract
backgroundThe aim of this multicentric prospective study in India was to assess the value of several microbiological tools that contribute to the diagnosis of tuberculosis (TB) according to HIV status.
methodsStandard microbiological tools on individual specimens were analyzed.
resultsAmong the 807 patients with active TB, 131 were HIV-infected, 316 HIV-uninfected and 360 had HIV-unknown status. Among the 980 non-active TB subjects, 559 were at low risk and 421 were at high risk of M. tuberculosis (Mtb) exposure. Sensitivity of smear microscopy (SM) was significantly lower in HIV-infected (42.2%) than HIV-uninfected (75.9%) (p = 0.0001) and HIV-unknown pulmonary TB patients (61.4%) (p = 0.004). Specificity was 94.5% in non-TB patients and 100% in health care workers (HCW) and healthy family contacts. Automated liquid culture has significantly higher diagnostic performances than solid culture, measured by sensitivity (74.7% vs. 55.9%) (p = 0.0001) and shorter median time to detection (TTD) (12.0 vs. 34.0 days) (p = 0.0001). Specificity was 100% in HCW and cured-TB patients, but was lower in non-TB patients (89%) due to isolation of Mycobacteria other than tuberculosis (MOTT). TTD by both methods was related to AFB score. Contamination rate was low (1.4%). AccuProbe hybridization technique detected Mtb in almost all culture-positive specimens, but MOTT were found in 4.7% with a significantly higher frequency in HIV-infected (15%) than HIV-uninfected TB patients (0.5%) (p = 0.0007). Pre-test classification significantly increased the diagnostic value of all microbiological tests in pulmonary TB patients (p<0.0001) but to a lesser degree in extrapulmonary TB patients.
conclusionsConventional microbiological tools led to results similar to those already described in India special features for HIV-infected TB patients included lower detection by SM and culture. New microbiological assays, such as the automated liquid culture system, showed increased accuracy and speed of detection.
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