ArticlePloS one2012
Optimization of cardiovascular stent against restenosis: factorial design-based statistical analysis of polymer coating conditions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Synthesis and Optimization of PEG-PLGA Immunotherapeutic Nanoparticles for the Controlled Release of IFNα.AAPS PharmSciTech · 2026Article
- Regenerative Medicine and Nanotechnology Approaches against Cardiovascular Diseases: Recent Advances and Future Prospective.Current stem cell research & therapy · 2025Review
- Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications.JACC. Basic to translational science · 2024Review
- Research progress of absorbable stents.International journal of medical sciences · 2024Review
- Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma-A Narrative Review.Pharmaceutics · 2023Review
- Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Advances in the development of biodegradable coronary stents: A translational perspective.Materials today. Bio · 2022Review
- Review
- Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Use of electron microscopy to study platelets and thrombi.Platelets · 2020Review
- Coating Techniques and Release Kinetics of Drug-Eluting Stents.Journal of medical devices · 2019Article
- Nanotechnology and stem cells in vascular biology.Vascular biology (Bristol, England) · 2019Review
- 3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair.Frontiers in bioengineering and biotechnology · 2019Article
- Recent Advances in Treatment of Coronary Artery Disease: Role of Science and Technology.International journal of molecular sciences · 2018Review
- Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles.Pharmaceutical research · 2017Article
- Drug- and Gene-eluting Stents for Preventing Coronary Restenosis.Chonnam medical journal · 2017Review
- Nanotechnology in diagnosis and treatment of coronary artery disease.Nanomedicine (London, England) · 2016Review
- Optimization of dexamethasone mixed nanomicellar formulation.AAPS PharmSciTech · 2014Article
- Nanofiber-coated drug eluting stent for the stabilization of mast cells.Pharmaceutical research · 2014Article
- Polymeric stent materials dysregulate macrophage and endothelial cell functions: implications for coronary artery stent.International journal of cardiology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to optimize the physicodynamic conditions of polymeric system as a coating substrate for drug eluting stents against restenosis. As Nitric Oxide (NO) has multifunctional activities, such as regulating blood flow and pressure, and influencing thrombus formation, a continuous and spatiotemporal delivery of NO loaded in the polymer based nanoparticles could be a viable option to reduce and prevent restenosis. To identify the most suitable carrier for S-Nitrosoglutathione (GSNO), a NO prodrug, stents were coated with various polymers, such as poly (lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG) and polycaprolactone (PCL), using solvent evaporation technique. Full factorial design was used to evaluate the effects of the formulation variables in polymer-based stent coatings on the GSNO release rate and weight loss rate. The least square regression model was used for data analysis in the optimization process. The polymer-coated stents were further assessed with Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy analysis (FTIR), Scanning electron microscopy (SEM) images and platelet adhesion studies. Stents coated with PCL matrix displayed more sustained and controlled drug release profiles than those coated with PLGA and PEG. Stents coated with PCL matrix showed the least platelet adhesion rate. Subsequently, stents coated with PCL matrix were subjected to the further optimization processes for improvement of surface morphology and enhancement of the drug release duration. The results of this study demonstrated that PCL matrix containing GSNO is a promising system for stent surface coating against restenosis.
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Registered trials
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