ArticleFrontiers in physiology2012
Integration of peroxisomes into an endomembrane system that governs cellular aging.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Metabolomic Profiling ofJournal of fungi (Basel, Switzerland) · 2026Article
- Peroxisomes in Alzheimer's disease: emerging mechanistic insights and therapeutic opportunities.Frontiers in aging neuroscience · 2026Review
- Investigating D-Amino Acid Oxidase Expression and Interaction Network Analyses in Pathways Associated With Cellular Stress: Implications in the Biology of Aging.Bioinformatics and biology insights · 2024Article
- Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation.Frontiers in cell and developmental biology · 2022Article
- Peroxisomes in host defense.PLoS pathogens · 2020Article
- Beyond the cell factory: Homeostatic regulation of and by the UPRScience advances · 2020Review
- Article
- Mechanisms by which PE21, an extract from the white willowOncotarget · 2019Article
- Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond.Plant molecular biology · 2019Article
- Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease.Histochemistry and cell biology · 2019Article
- Protective Effect of the Hexanic Extract ofAntioxidants (Basel, Switzerland) · 2019Article
- Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic.Frontiers in molecular neuroscience · 2019Article
- Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy.Molecular biology of the cell · 2018Article
- Some Metabolites Act as Second Messengers in Yeast Chronological Aging.International journal of molecular sciences · 2018Review
- Article
- The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilising activity.Histochemistry and cell biology · 2017Article
- Pex35 is a regulator of peroxisome abundance.Journal of cell science · 2017Article
- Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.Oxidative medicine and cellular longevity · 2017Review
- Six plant extracts delay yeast chronological aging through different signaling pathways.Oncotarget · 2016Article
- Autophagic degradation of peroxisomes in mammals.Biochemical Society transactions · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peroxisome is an organelle that has long been known for its essential roles in oxidation of fatty acids, maintenance of reactive oxygen species (ROS) homeostasis and anaplerotic replenishment of tricarboxylic acid (TCA) cycle intermediates destined for mitochondria. Growing evidence supports the view that these peroxisome-confined metabolic processes play an essential role in defining the replicative and chronological age of a eukaryotic cell. Much progress has recently been made in defining molecular mechanisms that link cellular aging to fatty acid oxidation, ROS turnover, and anaplerotic metabolism in peroxisomes. Emergent studies have revealed that these organelles not only house longevity-defining metabolic reactions but can also regulate cellular aging via their dynamic communication with other cellular compartments. Peroxisomes communicate with other organelles by establishing extensive physical contact with lipid bodies, maintaining an endoplasmic reticulum (ER) to peroxisome connectivity system, exchanging certain metabolites, and being involved in the bidirectional flow of some of their protein and lipid constituents. The scope of this review is to summarize the evidence that peroxisomes are dynamically integrated into an endomembrane system that governs cellular aging. We discuss recent progress in understanding how communications between peroxisomes and other cellular compartments within this system influence the development of a pro- or anti-aging cellular pattern. We also propose a model for the integration of peroxisomes into the endomembrane system governing cellular aging and critically evaluate several molecular mechanisms underlying such integration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.