Evidence map›Paper›PMID 22936897›Full record

ArticleFrontiers in neuroscience2012

Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function.

Adam D Norris, John A Calarco

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
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  8. Article
  9. Splicing to orchestrate cell fate.Molecular therapy. Nucleic acids · 2025
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam D NorrisFAS Center for Systems Biology, Harvard University Cambridge, MA, USA.
John A Calarco

Funding

Investigating the Role of Alternative Splicing Regulatory Networks in Nervous SysDP5OD009153 · OD · HARVARD UNIVERSITY · PI CALARCO, JOHN ANTHONY · 2011 to 2015
$2.1M
NIH HHS DP5 OD009153
6 · The paper itself

Abstract

Alternative pre-mRNA splicing has the potential to greatly diversify the repertoire of transcripts in multicellular organisms. Increasing evidence suggests that this expansive layer of gene regulation plays a particularly important role in the development and function of the nervous system, one of the most complex organ systems found in nature. In this review, we highlight recent studies that continue to emphasize the influence and contribution of alternative splicing regulation to various aspects of neuronal development in addition to its role in the mature nervous system.

Indexed as

alternative splicinggene regulationgenomicsnervous systemRNA processing

Identifiers

PMID22936897
PMCPMC3424503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.