ArticleDrug, healthcare and patient safety2012
Clinical use of antidepressant therapy and associated cardiovascular risk.
Article in Drug, healthcare and patient safety, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of Antidepressants With Atrial Fibrillation and Ventricular Arrhythmias: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- [Physical activity as therapeutic intervention for depression].Der Nervenarzt · 2017Pooled it
- Cardiovascular disease and depression: a bidirectional relationship and its clinical implications.Frontiers in psychiatry · 2025Review
- The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use.Therapeutic advances in psychopharmacology · 2024Review
- Serotonin antidepressants and atrial fibrillation burden from cardiac implantable electronic devices.Journal of arrhythmia · 2023Article
- Review
- The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine.Cureus · 2022Review
- Cardiovascular Events Associated with Antipsychotics in Newly Diagnosed Parkinson's Disease Patients: A Propensity Score Matched Cohort Study.International journal of general medicine · 2021Article
- Impact of Antidepressants on Cardiac Events and All-Cause Mortality in Parkinson's Disease: A National Data-Linkage Study.Neuropsychiatric disease and treatment · 2021Article
- Enhanced Integrated Behavioral Health Model Improves Depressive Symptoms in a Low-Income, Uninsured, Primarily Hispanic Population Served by a Free and Charitable Clinic.International journal of integrated care · 2020Article
- The association of depression and anxiety with cardiac autonomic activity: The role of confounding effects of antidepressants.Depression and anxiety · 2019Article
- Article
- All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Bradycardia caused by interaction of venlafaxine and cyclosporine: A case report.Caspian journal of internal medicine · 2019Article
- Risk of Cardiac Events Associated With Antidepressant Therapy in Patients With Long QT Syndrome.The American journal of cardiology · 2018Article
- Antidepressant Use by Class: Association with Major Adverse Cardiac Events in Patients with Coronary Artery Disease.Psychotherapy and psychosomatics · 2018Article
- Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications.Translational research : the journal of laboratory and clinical medicine · 2018Article
- Antidepressants and the risk of arrhythmia in elderly affected by a previous cardiovascular disease: a real-life investigation from Italy.European journal of clinical pharmacology · 2018Article
- Depressive symptom clusters as predictors of incident coronary artery disease: a 15-year prospective study.Psychosomatic medicine · 2014Article
- Cardiovascular considerations in antidepressant therapy: an evidence-based review.The journal of Tehran Heart Center · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of different psychotropic agents have been associated with an increased risk of cardiovascular disease, and these relationships have been difficult to interpret due to the presence of confounding factors. Recently, there has been renewed interest in the potential for certain antidepressants to cause QT prolongation, which is a predisposing factor for arrhythmia. However, the optimum means of determining QT remains contentious due to discrepancies between methods that may be readily applied in a clinical setting versus more detailed techniques during regulatory assessment. A number of different pharmacological mechanisms might explain the occurrence of adverse cardiac effects, and these differ according to the type of antidepressant agent. Emerging data indicate that citalopram exhibits a dose-effect relationship for QT prolongation. Whereas cardiotoxicity is readily apparent in the context of intentional antidepressant overdose, the occurrence of cardiac effects as a result of therapeutic administration is less certain. Pre-existing cardiac disease and other factors that independently predispose to arrhythmia are important considerations. Therefore, clinical judgment is needed to evaluate the overall risk or benefit of a particular antidepressant in any patient. Close monitoring should be considered for those at greatest risk of QT prolongation and arrhythmia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.