Evidence map›Paper›PMID 22936803›Full record

Trial reportThe Journal of biological chemistry2012

Ubiquitin E3 ligase A20 facilitates processing microbial product in nasal epithelial cells.

Yun-Fang An, Tong-Li Li, Xiao-Rui Geng, Gui Yang, Chang-Qing Zhao, Ping-Chang Yang

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Yun-Fang AnDepartment of Otolaryngology, Head and Neck Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Tong-Li LiDepartment of Otolaryngology, Shanxi Provincial People's Hospital, Taiyuan 030012, China; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada.
Xiao-Rui GengDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada.
Gui YangDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada.
Chang-Qing ZhaoDepartment of Otolaryngology, Head and Neck Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address: fahyj@126.com.
Ping-Chang YangDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada. Electronic address: yangp@mcmaster.ca.
McMaster University · CASecond Hospital of Shanxi Medical University · CNShaanxi Provincial People's Hospital · CNShanxi Medical University · CN

Funding

Canadian Institutes of Health Research 191063 aCanadian Institutes of Health Research 220058
6 · The paper itself

Abstract

Microbial products play a role in the pathogenesis of allergic diseases; ubiquitin E3 ligase A20 (A20) is an important molecule in regulating inflammation in the body. The present study aims to elucidate the role of A20 in processing the absorbed microbial products in nasal epithelial cells. Human nasal mucosal specimens were collected from patients with or without chronic rhinitis and analyzed by immunohistochemistry. Human nasal epithelial cell line, RPMI2650 cell, was employed to assess the role of A20 in processing the absorbed staphylococcal enterotoxin B (SEB). The RPMI2650 cells absorbed SEB in the culture. The increase in A20 was observed in RPMI2650 cells in parallel to the absorption of SEB. A20 is a critical molecule in the degradation of SEB in the nasal epithelial cells by promoting the tethering of endosomes and lysosomes. A20 plays a critical role in processing of the absorbed SEB in nasal epithelial cells.

Indexed as

ProteolysisAdultBacterial ProteinsBacterial ToxinsCell LineDNA-Binding ProteinsEndosomesEnterotoxinsEpithelial CellsFemaleHumansIntracellular Signaling Peptides and ProteinsLysosomesMaleNasal MucosaNuclear ProteinsBacterial ProteinsBacterial ToxinsDNA-Binding Proteinsenterotoxin B, staphylococcalEnterotoxinsIntracellular Signaling Peptides and ProteinsNuclear ProteinsTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3Ubiquitin-Protein Ligases

Identifiers

PMID22936803
PMCPMC3471685
OpenAlexW1968772479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.