Evidence map›Paper›PMID 22936795›Full record

Trial reportBMJ (Clinical research ed.)2012

Low glycaemic index diet in pregnancy to prevent macrosomia (ROLO study): randomised control trial.

Jennifer M Walsh, Ciara A McGowan, Rhona Mahony, Michael E Foley, Fionnuala M McAuliffe

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 151 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 20 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03146156 nacompletednot on this mapstarted 2017, after this paper: background citation

Lifestyle Intervention in Preparation for Pregnancy (LIPP)

TypeinterventionalSponsorTufts Medical CenterRan2017 to 2025Enrolled99ConditionsObesity, Lifestyle-related Condition, Macrosomia, FetalArmsLifestyle Intervention
NCT03607799 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes Mellitus

TypeinterventionalSponsorMcMaster UniversityRan2020 to 2025Enrolled140ConditionsDiabetes, GestationalArmsDietary Intervention, Control
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 20 syntheses or guidelines pooled it, 348 citations in OpenAlex.

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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jennifer M WalshUCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Ciara A McGowan
Rhona Mahony
Michael E Foley
Fionnuala M McAuliffe
National Maternity Hospital · IEUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine if a low glycaemic index diet in pregnancy could reduce the incidence of macrosomia in an at risk group.

designRandomised controlled trial.

settingMaternity hospital in Dublin, Ireland.

participants800 women without diabetes, all in their second pregnancy between January 2007 to January 2011, having previously delivered an infant weighing greater than 4 kg.

interventionWomen were randomised to receive no dietary intervention or start on a low glycaemic index diet from early pregnancy. MAIN OUTCOMES: The primary outcome measure was difference in birth weight. The secondary outcome measure was difference in gestational weight gain.

resultsNo significant difference was seen between the two groups in absolute birth weight, birthweight centile, or ponderal index. Significantly less gestational weight gain occurred in women in the intervention arm (12.2 v 13.7 kg; mean difference -1.3, 95% confidence interval -2.4 to -0.2; P=0.01). The rate of glucose intolerance was also lower in the intervention arm: 21% (67/320) compared with 28% (100/352) of controls had a fasting glucose of 5.1 mmol/L or greater or a 1 hour glucose challenge test result of greater than 7.8 mmol/L (P=0.02).

conclusionA low glycaemic index diet in pregnancy did not reduce the incidence of large for gestational age infants in a group at risk of fetal macrosomia. It did, however, have a significant positive effect on gestational weight gain and maternal glucose intolerance.

trial registrationCurrent Controlled Trials ISRCTN54392969.

Indexed as

Diet, Carbohydrate-RestrictedAdultAnthropometryBody Mass IndexDietary CarbohydratesFemaleFetal MacrosomiaGestational AgeGlucose Tolerance TestGlycemic IndexHumansIncidenceMaternal Nutritional Physiological PhenomenaPregnancyPregnancy ComplicationsRisk FactorsDietary Carbohydrates

Identifiers

PMID22936795
PMCPMC3431285
OpenAlexW2043043388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.