ArticleScience (New York, N.Y.)2012
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
101 citing papers in PubMed, 327 citations in OpenAlex.
- Hydrogen bond reorganization activates water radical chemistry for COScience advances · 2026Article
- A metabolite extracted from Escherichia coli suppresses tau aggregation.The Biochemical journal · 2026Article
- From Discovery to Manufacturing: A Quantitative Review of Phosphonates and Strategies for High-Titer Production.Microorganisms · 2026Review
- A novel North Sea ammonia-oxidizing archaeon Nitrosarchaeum marinum leverages a high abundance of transport systems to grow over a wide salinity range.FEMS microbiology ecology · 2026Article
- Atmospheric deposition enhances marine methane production and emissions from global oceans.Nature communications · 2026Article
- Biocatalytic cascade for the synthesis of methylphosphonate from phosphoenolpyruvate.Microbial cell factories · 2025Article
- Article
- Diverse marineMarine life science & technology · 2025Article
- The microbial phosphorus cycle in aquatic ecosystems.Nature reviews. Microbiology · 2025Review
- Proteomic evidence for aerobic methane production in groundwater by methylotrophic Methylotenera.The ISME journal · 2025Article
- Phosphonate-driven oxic CHISME communications · 2025Article
- Adaptive Responses of Cyanobacteria to Phosphate Limitation: A Focus on Marine Diazotrophs.Environmental microbiology · 2024Review
- Phosphonoalamides Reveal the Biosynthetic Origin of Phosphonoalanine Natural Products and a Convergent Pathway for Their Diversification.Angewandte Chemie (International ed. in English) · 2024Article
- Functional prediction of proteins from the human gut archaeome.ISME communications · 2024Article
- Correlation of methane production with physiological traits inFrontiers in microbiology · 2024Article
- Oxic methane production from methylphosphonate in a large oligotrophic lake: limitation by substrate and organic carbon supply.Applied and environmental microbiology · 2023Article
- Transcriptomic Insights into Archaeal Nitrification in the Amundsen Sea Polynya, Antarctica.Journal of microbiology (Seoul, Korea) · 2023Article
- Effects of 5-year experimental warming in the Alpine belt on soil Archaea: Multi-omics approaches and prospects.Environmental microbiology reports · 2023Article
- Archean phosphorus recycling facilitated by ultraviolet radiation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The facilitating role of phycospheric heterotrophic bacteria in cyanobacterial phosphonate availability and Microcystis bloom maintenance.Microbiome · 2023Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Relative to the atmosphere, much of the aerobic ocean is supersaturated with methane; however, the source of this important greenhouse gas remains enigmatic. Catabolism of methylphosphonic acid by phosphorus-starved marine microbes, with concomitant release of methane, has been suggested to explain this phenomenon, yet methylphosphonate is not a known natural product, nor has it been detected in natural systems. Further, its synthesis from known natural products would require unknown biochemistry. Here we show that the marine archaeon Nitrosopumilus maritimus encodes a pathway for methylphosphonate biosynthesis and that it produces cell-associated methylphosphonate esters. The abundance of a key gene in this pathway in metagenomic data sets suggests that methylphosphonate biosynthesis is relatively common in marine microbes, providing a plausible explanation for the methane paradox.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.