ArticleScience (New York, N.Y.)2012
A gain-of-function polymorphism controlling complex traits and fitness in nature.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 173 citations in OpenAlex.
- Convergence and constraint in glucosinolate evolution across the Brassicaceae.The Plant cell · 2025Article
- Are complex traits underpinned by polygenic molecular traits? A reflection on the complexity of gene expression.Plant & cell physiology · 2025Review
- Increasing Aridity May Threaten the Maintenance of a Plant Defence Polymorphism.Ecology letters · 2025Article
- Article
- Gain- and loss-of-function alleles within signaling pathways lead to phenotypic diversity among individuals.iScience · 2024Article
- Adaptive modifications in plant sulfur metabolism over evolutionary time.Journal of experimental botany · 2024Review
- Genomic approaches to enhance adaptive plasticity to cope with soil constraints amidst climate change in wheat.The plant genome · 2024Review
- Aphid Resistance Segregates Independently of Cardenolide and Glucosinolate Content in anPlants (Basel, Switzerland) · 2024Article
- A large-effect fitness trade-off across environments is explained by a single mutation affecting cold acclimation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Aphid resistance segregates independently of cardiac glycoside and glucosinolate content in anbioRxiv : the preprint server for biology · 2024Article
- Genetic basis and selection of glyceollin elicitation in wild soybean.Frontiers in plant science · 2024Article
- Soil variation among natural habitats alters glucosinolate content in a wild perennial mustard.Journal of experimental botany · 2023Article
- Novel host unmasks heritable variation in plant preference within an insect population.Evolution; international journal of organic evolution · 2022Article
- Genetics of adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome-wide association mapping within a localPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Globally Relaxed Selection and Local Adaptation in Boechera stricta.Genome biology and evolution · 2022Article
- Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.Nature ecology & evolution · 2021Article
- Genetic architecture and adaptation of flowering time among environments.The New phytologist · 2021Article
- The ecological, genetic and genomic architecture of local adaptation and population differentiation inProceedings. Biological sciences · 2021Article
- The Cell Differentiation of Idioblast Myrosin Cells: Similarities With Vascular and Guard Cells.Frontiers in plant science · 2021Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that influence polymorphisms in nature. We cloned a quantitative trait locus that controls plant defensive chemistry, damage by insect herbivores, survival, and reproduction in the natural environments where this polymorphism evolved. These ecological effects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling this variation and by two selectively favored amino acid changes in the glucosinolate-biosynthetic cytochrome P450 proteins that they encode. These changes cause a gain of novel enzyme function, modulated by allelic differences in catalytic rate and gene copy number. Ecological interactions in diverse environments likely contribute to the widespread polymorphism of this biochemical function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.