SynthesisBlood2012
Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.
Registry-linked trialOpen access · greenAbstract readLetterMeta-Analysis
In one paragraph
Synthesis in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02824471 (Sickle Cell Disease), which is not on this map. Cited by 54 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sickle Cell Disease (SCD) Biochip': Towards a Simple and Reliable Way to Monitor Sickle Cell Disease
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies.International journal of molecular sciences · 2024Pooled it
- Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- The CYB5R3American journal of hematology · 2020Trial
- High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia.Annals of hematology · 2020Trial
- Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification.American journal of hematology · 2026Article
- The Epidemiology of Sickle Cell Disease in Sub-Saharan Africa: Current Knowledge and Gaps to be Filled.American journal of hematology · 2026Review
- Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications.Mediterranean journal of hematology and infectious diseases · 2026Review
- MAZ regulates fetal hemoglobin repression by activating MYB transcription.Scientific reports · 2025Article
- FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries.Nature communications · 2025Article
- Haplotype-Resolved Genotyping and Association Analysis of 1,020 β-Thalassemia Patients by Targeted Long-Read Sequencing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Prevalence and Impact of HMOX1 Polymorphism (rs2071746: A > T) in Indian Sickle Cell Disease Patients.Journal of laboratory physicians · 2023Article
- Fetal hemoglobin modulates neurocognitive performance in sickle cell anemiaCurrent research in translational medicine · 2022Article
- Childhood stroke.Nature reviews. Disease primers · 2022Review
- Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts.Frontiers in genetics · 2022Review
- A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.Blood advances · 2021Article
- Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation.Genome medicine · 2021Review
- Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes.Journal of clinical medicine · 2020Review
- Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients.Annals of hematology · 2020Article
- Functional polymorphisms of BCL11A and HBS1L-MYB genes affect both fetal hemoglobin level and clinical outcomes in a cohort of children with sickle cell anemia.Annals of hematology · 2020Article
- BCL2L1 is associated with γ-globin gene expression.Blood advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 11 institutions in 1 country.
Harold T Bae
Clinton T Baldwin
Paola Sebastiani
Marilyn J Telen
Allison Ashley-Koch
Melanie Garrett
W Craig Hooper
Christopher J Bean
Michael R Debaun
Dan E Arking
Pallav Bhatnagar
James F Casella
Jeffrey Renn Keefer
Emily Barron-Casella
Victor Gordeuk
Gregory J Kato
Caterina Minniti
James Taylor
Andrew Campbell
Lori Luchtman-Jones
Carolyn Hoppe
Mark T Gladwin
Yingze Zhang
Martin H Steinberg
Boston University · USDuke University · USJohns Hopkins Medicine · USNational Heart Lung and Blood Institute · USCenters for Disease Control and Prevention · USJohns Hopkins University · USUniversity of Pittsburgh · USChildren's National · USUniversity of Illinois Chicago · USUniversity of Michigan–Ann Arbor · USVanderbilt University · US
Funding
Silent Cerebral Infarct Multi-Center Clinical TrialU01NS042804 · NINDS · WASHINGTON UNIVERSITY · PI DEBAUN, MICHAEL R. · 2003 to 2010
$20.7MUVDM01RR010284 · NCRR · HOWARD UNIVERSITY · PI TAYLOR, ROBERT E. · 1996 to 2010
$17.4MPulmonary Hypertension and the Hypoxic Response in SCDR01HL079912 · NHLBI · HOWARD UNIVERSITY · PI GORDEUK, VICTOR R · 2005 to 2008
$7.4MPulmonary Hypertension in SCDR01HL079915 · NHLBI · DUKE UNIVERSITY · PI TELEN, MARILYN J · 2005 to 2008
$6.7MGenome-Wide Association Studies in Sickle Cell Anemia and in CentenariansR01HL087681 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2007 to 2010
$6.0MGenomic Determinants of Phenotypes of Sickle Cell DiseaseZIAHL006160 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI TAYLOR, JAMES · 2012 to 2016
$5.1MSickle cell scholar componentU54HL090515 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CASELLA, JAMES F · 2008 to 2011
$3.8MOutcome Modifying Genes in Sickle Cell DiseaseR01HL068959 · NHLBI · DUKE UNIVERSITY · PI TELEN, MARILYN J · 2001 to 2005
$3.6MGenetic Diversity of Sickle Cell AnemiaRC2HL101212 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2009 to 2010
$3.0MHoward University Research Scientist AwardR25HL003679 · NHLBI · HOWARD UNIVERSITY · PI NEKHAI, SERGEI · 2005 to 2009
$1.7MTreatment of PH and SCD with Sildenafil TherapyZIAHL005116 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KATO, GREGORY · 2009 to 2012
$1.4MPulmonary Hypertension and the Hypoxic Response in SCD (PUSH)ZIAHL006016 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KATO, GREGORY · 2009 to 2013
$624kIntramural NIH HHS ZIA HL005116NCRR NIH HHS 2M01 RR10284-10NCRR NIH HHS M01 RR010284NHGRI NIH HHS HHSN268200782096CNHLBI NIH HHS 2R25 HL003679-8NHLBI NIH HHS HL079915NHLBI NIH HHS HL68959NHLBI NIH HHS R01 HL068959NHLBI NIH HHS R01 HL079912NHLBI NIH HHS R01 HL079915NHLBI NIH HHS R01 HL087681NHLBI NIH HHS R01 HL87681NHLBI NIH HHS R25 HL003679NHLBI NIH HHS RC2 HL101212NHLBI NIH HHS U54 HL090515NHLBI NIH HHS U54HL090515NINDS NIH HHS 5-U01-NS042804-07NINDS NIH HHS U01 NS042804
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anemia, Sickle CellBlack or African AmericanCarrier ProteinsDNA, IntergenicFetal HemoglobinGenetic VariationGenome-Wide Association StudyHumansNuclear ProteinsPolymorphism, Single NucleotideProto-Oncogene Proteins c-mybRepressor ProteinsBCL11A protein, humanCarrier ProteinsDNA, IntergenicFetal HemoglobinNuclear ProteinsProto-Oncogene Proteins c-mybRepressor Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02824471ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.