ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis.Journal of neuropathology and experimental neurology · 2024Article
- SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex.Communications biology · 2022Article
- Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Neurochemistry of the Kölliker-Fuse nucleus from a respiratory perspective.Journal of neurochemistry · 2021Review
- Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice.Frontiers in molecular neuroscience · 2018Article
- Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage in newborn piglets.Pediatric research · 2017Article
- Evaluating the control: minipump implantation and breathing behavior in the neonatal rat.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Sudden Unexpected Death in Fetal Life Through Early Childhood.Pediatrics · 2016Article
- Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice.Respiratory physiology & neurobiology · 2016Article
- Article
- Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity.Journal of neurophysiology · 2015Article
- Medullary serotonin neurons are CO2 sensitive in situ.Journal of neurophysiology · 2013Article
- Point process modeling of interbreath interval: a new approach for the assessment of instability of breathing in neonates.IEEE transactions on bio-medical engineering · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We hypothesized that absence of the 5-HT(1A) receptor would negatively affect the development of cardiorespiratory control. In conscious wild type (WT) and 5-HT(1A) receptor knockout (KO) mice, we measured resting ventilation (Ve), oxygen consumption (Vo(2)), heart rate (HR), breathing and HR variability, and the hypercapnic ventilatory response (HCVR) at postnatal day 5 (P5), day 15 (P15), and day 25 (P25). In KO mice compared with WT, we found a 17% decrease in body weight at only P5 (P < 0.01) and no effect on Vo(2). Ve was significantly (P < 0.001) lower at P5 and P25, but there was no effect on the HCVR. Breathing variability (interbreath interval), measured by standard deviation, the root mean square of the standard deviation (RMSSD), and the product of the major (L) and minor axes (T) of the Poincaré first return plot, was 57% to 187% higher only at P5 (P < 0.001). HR was 6-10% slower at P5 (P < 0.001) but 7-9% faster at P25 (P < 0.001). This correlated with changes in the spectral analysis of HR variability; the low frequency to high frequency ratio was 47% lower at P5 but 68% greater at P25. The RMSSD and (L × T) of HR variability were ~2-fold greater at P5 only (P < 0.001; P < 0.05). We conclude that 5-HT(1A) KO mice have a critical period of potential vulnerability at P5 when pups hypoventilate and have a slower respiratory frequency and HR with enhanced variability of both, suggesting abnormal maturation of cardiorespiratory control.
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