ArticleScience (New York, N.Y.)2012
A high-coverage genome sequence from an archaic Denisovan individual.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 898 papers.
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Who cites it
898 citing papers in PubMed.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- Genomic structural variations distinguishing archaic and modern humans are associated with neurodevelopment.iScience · 2026Article
- The gene-regulatory evolution of the human skeleton.Nature · 2026Article
- Comparing the Performance of Double-Stranded and Single-Stranded DNA Libraries for Ancient Oral Microbiome Reconstruction.Molecular ecology resources · 2026Article
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- Jomon genomics reveal cold adaptation in Upper Paleolithic hunter-gatherers of eastern Eurasia.Science advances · 2026Article
- On the ancestry and evolution of the extinct dire wolf.Cell genomics · 2026Article
- Archaic ancestry inference in imputed ancient human genomes.Nature communications · 2026Article
- Evolution-guided yeast complementation reveals functional differences in human PSPH variants.FEBS open bio · 2026Article
- Faster inference of complex demographic models from large allele frequency spectra.Bioinformatics (Oxford, England) · 2026Article
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- Molecular Clock Dating of Ancient Environmental DNA Reveals Damage Beyond Deamination.bioRxiv : the preprint server for biology · 2026Article
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
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- Scalable ARG-free Detection of Denisovan-mediated Superarchaic Introgression Reveals Heterogeneous Patterns across Populations.bioRxiv : the preprint server for biology · 2026Article
- Metagenomic peek into a corn mummy.Scientific reports · 2026Article
- Mesopotamian ancient DNA reveals Iron Age integration of heterogeneous Bronze Age genetic ancestries following resettlement.Genome biology · 2026Article
838 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors.
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Abstract
We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
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