Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Health-related quality of life and inflammatory markers in malignant pleural mesothelioma.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Patient-Reported Outcomes as Prognostic Indicators for Overall Survival in Cancer: A Systematic Review and Meta-Analysis.JAMA oncology · 2025Pooled it
- Psychological Distress in Patients With Asbestos-Related Diseases and Their Families: A Systematic Literature Review.Psycho-oncology · 2025Pooled it
- Global quality of life and mortality risk in patients with cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Health Utility and Symptom Scores in Patients With Advanced Malignant Pleural Mesothelioma Treated in a Real-World Setting.JTO clinical and research reports · 2025Article
- Review
- Rehabilitation for Functioning and Quality of Life in Patients with Malignant Pleural Mesothelioma: A Scoping Review.Current oncology (Toronto, Ont.) · 2024Article
- Review
- The usefulness and prognostic value of Memorial Symptom Assessment-Short Form and Condensed Memorial Symptom Assessment Scale in assessment of lung cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Correlations of health-related quality of life with serum inflammatory indicators IL-8 and mIBI in patients with hepatocellular carcinoma.Cancer management and research · 2019Article
- The use of patient-reported outcome measures (PROMs) in the management of malignant pleural mesothelioma: a descriptive literature survey.Translational lung cancer research · 2018Article
- Symptoms in Advanced Cancer Patients in a Greek Hospital: a Descriptive StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study.BMC cancer · 2018Article
- Survival prediction in mesothelioma using a scalable Lasso regression model: instructions for use and initial performance using clinical predictors.BMJ open respiratory research · 2018Article
- Prognostic significance of neutrophil-to-lymphocyte ratio in patients with malignant pleural mesothelioma: a meta-analysis.Oncotarget · 2017Article
- Physical function and health-related quality of life in patients undergoing surgical treatment for malignant pleural mesothelioma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer.BMC cancer · 2016Article
- The effect of chemotherapy on health-related quality of life in mesothelioma: results from the SWAMP trial.British journal of cancer · 2015Observational
- Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis.Annals of thoracic medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMalignant pleural mesothelioma (MPM) is a highly aggressive and symptomatic disease. We examined the relationship between health-related quality of life (HRQoL) and inflammatory markers, and the prognostic role of HRQoL in MPM patients.
methodsMPM patients from two parallel phase II studies (thalidomide alone or thalidomide with chemotherapy) were included. HRQoL was assessed at baseline using the modified Lung Cancer Symptom Scale (LCSS). Baseline inflammatory markers and cytokines were measured. Spearman correlation was used to examine the relationship between inflammatory markers and HRQoL measures. The prognostic value of the HRQoL domains was examined using Cox proportional hazard model.
resultsSixty-three patients were included: median age 61 years (range 44-79); 82% male; 77% Eastern Cooperative Oncology Group (ECOG) performance status 0-1; 44% epithelial histology subtype. Baseline systemic symptoms of anorexia and fatigue, the summation symptoms of overall symptomatic distress, interference with normal activity and global QoL and the aggregate score of total LCSS score were all associated with elevated neutrophil-to-lymphocyte ratio, C-reactive protein and vascular endothelial growth factor levels at baseline (rho ≥ 0.25; p < 0.05). Baseline anorexia, fatigue, cough, dyspnoea, pain, overall symptomatic distress, interference with normal activity, global QoL and total LCSS score were all significantly related to survival (p < 0.05) after adjusting for established prognostic factors (age, gender, histological subtype and performance status) and treatment effect.
conclusionsIn conclusion, HRQoL seems to relate to a patient's systemic inflammatory status and is associated with survival in MPM patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.