ArticleAmerican journal of respiratory and critical care medicine2012
Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 243 citations in OpenAlex.
- Interventions to reduce ambient particulate matter air pollution and their effect on health.The Cochrane database of systematic reviews · 2019Pooled it
- Indoor particulate matter concentrations and air cleaner intervention association with biomarkers in former smokers with COPD.Environmental research · 2024Trial
- A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability.Particle and fibre toxicology · 2014Trial
- Mega-Events, Air Pollution and Health Outcomes: A Systematic Review.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Investigating the inflammatory response to exposure of ultrafine TiOBiochemistry and biophysics reports · 2026Article
- Air pollution and mortality in acute lymphoblastic leukemia patients across different age groups in Northern Thailand (1999-2020).PloS one · 2026Article
- How Do Household Energy Transitions Work?Research report (Health Effects Institute) · 2025Article
- Particulate matter air pollution: effects on the respiratory system.The Journal of clinical investigation · 2025Review
- Health and economic benefits of energy, urban planning, and food interventions that lower greenhouse gas emissions.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- The Dark Triad of Particulate Matter, Oxidative Stress and Coronary Artery Disease: What About the Antioxidant Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- Impacts of Vehicle Emission Regulations and Local Congestion Policies on Birth Outcomes Associated with Traffic Air Pollution.Research report (Health Effects Institute) · 2025Article
- Environmental Risk Factors for Acute Respiratory Distress Syndrome.Clinics in chest medicine · 2024Review
- Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress.Antioxidants (Basel, Switzerland) · 2024Article
- Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Associations between Changes in Exposure to Air Pollutants due to Relocation and the Incidence of 14 Major Disease Categories and All-Cause Mortality: A Natural Experiment Study.Environmental health perspectives · 2024Article
- Effects of PMEnvironment & health (Washington, D.C.) · 2024Article
- Alginate Oligosaccharide Alleviates Lipopolysaccharide-Induced Apoptosis and Inflammatory Response of Rumen Epithelial Cells through NF-κB Signaling Pathway.Animals : an open access journal from MDPI · 2024Article
- Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
rationaleUnprecedented pollution control actions during the Beijing Olympics provided a quasi-experimental opportunity to examine biologic responses to drastic changes in air pollution levels.
objectivesTo determine whether changes in levels of biomarkers reflecting pulmonary inflammation and pulmonary and systemic oxidative stress were associated with changes in air pollution levels in healthy young adults.
methodsWe measured fractional exhaled nitric oxide, a number of exhaled breath condensate markers (H(+), nitrite, nitrate, and 8-isoprostane), and urinary 8-hydroxy-2-deoxyguanosine in 125 participants twice in each of the pre- (high pollution), during- (low pollution), and post-Olympic (high pollution) periods. We measured concentrations of air pollutants near where the participants lived and worked. We used mixed-effects models to estimate changes in biomarker levels across the three periods and to examine whether changes in biomarker levels were associated with changes in pollutant concentrations, adjusting for meteorologic parameters. MEASUREMENTS AND MAIN
resultsFrom the pre- to the during-Olympic period, we observed significant and often large decreases (ranging from -4.5% to -72.5%) in levels of all the biomarkers. From the during-Olympic to the post-Olympic period, we observed significant and larger increases (48-360%) in levels of these same biomarkers. Moreover, increased pollutant concentrations were consistently associated with statistically significant increases in biomarker levels.
conclusionsThese findings support the important role of oxidative stress and that of pulmonary inflammation in mediating air pollution health effects. The findings demonstrate the utility of novel and noninvasive biomarkers in the general population consisting largely of healthy individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.