ReviewBiotechnology letters2012
Metabolic shifts: a fitness perspective for microbial cell factories.
Review in Biotechnology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Alkaline pH-Driven Metabolic Plasticity of Lactococcus lactis FM03.Environmental microbiology · 2025Article
- Epigenome Engineering Using dCas Systems for Biomedical Applications and Biotechnology: Current Achievements, Opportunities and Challenges.International journal of molecular sciences · 2025Review
- A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations.PLoS computational biology · 2025Article
- Single-cell analysis reveals an active and heterotrophic microbiome in the Guaymas Basin deep subsurface with significant inorganic carbon fixation by heterotrophs.Applied and environmental microbiology · 2024Article
- Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments.Molecular systems biology · 2021Article
- Seeding the idea of encapsulating a representative synthetic metagenome in a single yeast cell.Nature communications · 2021Article
- Transcriptome Analysis Reveals Catabolite Control Protein A Regulatory Mechanisms Underlying Glucose-Excess or -Limited Conditions in a Ruminal Bacterium,Frontiers in microbiology · 2021Article
- Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs.Microbial cell factories · 2020Article
- Evolution of mutualistic behaviour between Chlorella sorokiniana and Saccharomyces cerevisiae within a synthetic environment.Journal of industrial microbiology & biotechnology · 2020Article
- The common message of constraint-based optimization approaches: overflow metabolism is caused by two growth-limiting constraints.Cellular and molecular life sciences : CMLS · 2020Review
- A General Process-Based Model for Describing the Metabolic Shift in Microbial Cell Cultures.Frontiers in microbiology · 2020Article
- Modelling overflow metabolism in Escherichia coli with flux balance analysis incorporating differential proteomic efficiencies of energy pathways.BMC systems biology · 2019Article
- Using drug-loaded pH-responsive poly(4-vinylpyridine) microspheres as a new strategy for intelligent controlling of Lactobacillus plantarum contamination in bioethanol fermentation.World journal of microbiology & biotechnology · 2018Article
- A mathematical framework for yield (vs. rate) optimization in constraint-based modeling and applications in metabolic engineering.Metabolic engineering · 2018Article
- Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield.PLoS computational biology · 2018Article
- Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death.Cell cycle (Georgetown, Tex.) · 2018Review
- Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome.PloS one · 2017Article
- Evolution across the Curriculum: Microbiology.Journal of microbiology & biology education · 2016Article
- Synthetic Ecology of Microbes: Mathematical Models and Applications.Journal of molecular biology · 2016Review
- Toward Multiscale Models of Cyanobacterial Growth: A Modular Approach.Frontiers in bioengineering and biotechnology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Performance of industrial microorganisms as cell factories is limited by the capacity to channel nutrients to desired products, of which optimal production usually requires careful manipulation of process conditions, or strain improvement. The focus in process improvement is often on understanding and manipulating the regulation of metabolism. Nonetheless, one encounters situations where organisms are remarkably resilient to further optimization or their properties become unstable. Therefore it is important to understand the origin of these apparent limitations to find whether and how they can be improved. We argue that by considering fitness effects of regulation, a more generic explanation for certain behaviour can be obtained. In this view, apparent process limitations arise from trade-offs that cells faced as they evolved to improve fitness. A deeper understanding of such trade-offs using a systems biology approach can ultimately enhance performance of cell factories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.