Trial reportJournal of general internal medicine2013
Paced respiration for vasomotor and other menopausal symptoms: a randomized, controlled trial.
Trial report in Journal of general internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00819182 (Breathe-intervention for Hot Flashes, Associated Outcomes, and Interference), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Breathe-intervention for Hot Flashes, Associated Outcomes, and Interference
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Respiratory Physiotherapy Intervention Strategies in the Sequelae of Breast Cancer Treatment: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Evaluating the Effects of Symptom Monitoring on Menopausal Health Outcomes: A Systematic Review and Meta-Analysis.Frontiers in global women's health · 2021Pooled it
- Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review.BJOG : an international journal of obstetrics and gynaecology · 2020Pooled it
- Systematic review of sleep disorders in cancer patients: can the prevalence of sleep disorders be ascertained?Cancer medicine · 2015Pooled it
- Evaluating the Sleep Hygiene Awareness and Practice Scale in Midlife Women With and Without Breast Cancer.Journal of nursing measurement · 2016Trial
- Device-guided slow-paced respiration for menopausal hot flushes: a randomized controlled trial.Obstetrics and gynecology · 2015Trial
- Effects of stellate ganglion block on vasomotor symptoms: findings from a randomized controlled clinical trial in postmenopausal women.Menopause (New York, N.Y.) · 2014Trial
- Trial
- Interventions to Improve Sexual Health in Women Living with and Surviving Cancer: Review and Recommendations.Cancers · 2021Review
- Focusing on fidelity: narrative review and recommendations for improving intervention fidelity within trials of health behaviour change interventions.Health psychology and behavioral medicine · 2020Review
- Management of Potential Long-Term Toxicities in Breast Cancer Patients.Current breast cancer reports · 2016Article
- Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women.Menopause (New York, N.Y.) · 2016Article
- Management of Menopausal Symptoms.Obstetrics and gynecology · 2015Review
- Insomnia and sleep apnea in midlife women: prevalence and consequences to health and functioning.F1000prime reports · 2015Review
- Somatosensory amplification and menopausal symptoms in breast cancer survivors and midlife women.Maturitas · 2014Article
- Risk factors, pathophysiology, and treatment of hot flashes in cancer.CA: a cancer journal for clinicians · 2013Review
- Description of an Audio-Based Paced Respiration Intervention for Vasomotor Symptoms.Music and medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPaced respiration has been internationally recommended for vasomotor symptom management, despite limited empirical evidence.
objectiveTo evaluate efficacy of a paced respiration intervention against breathing control and usual care control for vasomotor and other menopausal symptoms.
designA 16-week, 3-group, partially blinded, controlled trial with 2:2:1 randomization and stratification by group (breast cancer, no cancer), in a Midwestern city and surrounding area.
participantsTwo hundred and eighteen randomized women (96 breast cancer survivors, 122 menopausal women without cancer), recruited through community mailings and registries (29 % minority).
interventionsTraining, home practice support, and instructions to use the breathing at the time of each hot flash were delivered via compact disc with printed booklet (paced respiration intervention) or digital videodisc with printed booklet (fast shallow breathing control). Usual care control received a letter regarding group assignment. MAIN MEASURES: Hot flash frequency, severity, and bother (primary); hot flash interference in daily life, perceived control over hot flashes, and mood and sleep disturbances (secondary). Intervention performance, adherence, and adverse events were assessed. KEY
resultsThere were no significant group differences for primary outcomes at 8-weeks or 16-weeks post-randomization. Most intervention participants did not achieve 50 % reduction in vasomotor symptoms, despite demonstrated ability to correctly do paced respiration and daily practice. Statistically significant differences in secondary outcomes at 8 and 16 weeks were small, not likely to be clinically relevant, and as likely to favor intervention as breathing control.
conclusionsPaced respiration is unlikely to provide clinical benefit for vasomotor or other menopausal symptoms in breast cancer survivors or menopausal women without cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.