Sting of Alzheimer's failures offset by upcoming prevention trials.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

49 citing papers in PubMed.

1. Simulating effects of biomarker enrichment on Alzheimer's disease prevention trials: conceptual framework and example.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014
   Trial
2. Artificial intelligence and multiomics integration for Parkinson's disease drug development.Molecules and cells · 2026
   Review
3. Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons.Autophagy · 2025
   Article
4. Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants.Degenerative neurological and neuromuscular disease · 2024
   Review
5. Structural biology of cell surface receptors implicated in Alzheimer's disease.Biophysical reviews · 2022
   Review
6. Age at onset in genetic prion disease and the design of preventive clinical trials.Neurology · 2019
   Article
7. Exploring the Multi-Target Neuroprotective Chemical Space of Benzofuran Scaffolds: A New Strategy in Drug Development for Alzheimer's Disease.Frontiers in pharmacology · 2019
   Review
8. Subthreshold Amyloid Predicts Tau Deposition in Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
   Article
9. Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.Biological psychiatry · 2018
   Article
10. Iron and Alzheimer's Disease: From Pathogenesis to Therapeutic Implications.Frontiers in neuroscience · 2018
    Review
11. Resveratrol for Alzheimer's disease.Annals of the New York Academy of Sciences · 2017
    Review
12. The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.Molecular medicine (Cambridge, Mass.) · 2017
    Article
13. Human ApoE ɛ2 Promotes Regulatory Mechanisms of Bioenergetic and Synaptic Function in Female Brain: A Focus on V-type H+-ATPase.Journal of Alzheimer's disease : JAD · 2016
    Article
14. Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease.Neurobiology of aging · 2016
    Article
15. Estrogen receptor β in Alzheimer's disease: From mechanisms to therapeutics.Ageing research reviews · 2015
    Review
16. Parkinson's disease: From human genetics to clinical trials.Science translational medicine · 2015
    Article
17. Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations.Movement disorders : official journal of the Movement Disorder Society · 2015
    Article
18. Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Chemical reviews · 2015
    Review
19. Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies.Scientific reports · 2015
    Article
20. S-Nitrosylation in Alzheimer's disease.Molecular neurobiology · 2015
    Review

Corrections and comments

• Commented on by
  Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease.2013
• Commented on by
  A new roadmap for drug development for Alzheimer's disease.2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as