ArticleJournal of perinatology : official journal of the California Perinatal Association2013
Changes in regional tissue oxygenation saturation and desaturations after red blood cell transfusion in preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Effect of Liberal versus Restrictive Haemoglobin Thresholds on Cerebral Tissue Oxygenation in Preterm Infants: A Systematic Review and Meta-Analysis.Neonatology · 2026Pooled it
- The near-infrared spectroscopy to evaluate neonatal improvement after transfusion: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy-A Systematic Qualitative Review.Frontiers in pediatrics · 2021Pooled it
- Anemia and Red Blood Cell Transfusions, Cerebral Oxygenation, Brain Injury and Development, and Neurodevelopmental Outcome in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2021Pooled it
- Differences in Cerebral Tissue Oxygenation in Preterm Neonates Receiving Adult or Cord Blood Red Blood Cell Transfusions.JAMA network open · 2023Trial
- Tissue Oxygenation Changes After Transfusion and Outcomes in Preterm Infants: A Secondary Near-Infrared Spectroscopy Study of the Transfusion of Prematures Randomized Clinical Trial (TOP NIRS).JAMA network open · 2023Trial
- Non-invasive assessment of muscle oxygenation may aid in optimising transfusion threshold decisions in ambulatory paediatric patients.Transfusion medicine (Oxford, England) · 2017Trial
- Pulse Oximetry Histogram Profiles Before and After Red Blood Cell Transfusion in Very Preterm Infants: A Prospective Observational Cohort.Children (Basel, Switzerland) · 2026Article
- A narrative review of the clinical applications of renal NIRS and integration with cerebral NIRS in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit.Pediatric nephrology (Berlin, Germany) · 2025Review
- Utility of Abdominal Near Infrared Spectroscopy in the Management of Neonates: A Review.American journal of perinatology · 2025Review
- The Clinical Relevance of Overnight Oximetry in the Diagnosis of Intermittent Desaturations and the Need for Home Oxygen in the Near-Term and Term Infant.Children (Basel, Switzerland) · 2025Review
- Hybrid diffuse optical appraisal of peripheral and cerebral changes in critically ill patients receiving red blood cell transfusion.Biophotonics discovery · 2025Article
- Cerebral near-infrared spectroscopy guided neonatal intensive care management for the preterm infant.Pediatric research · 2024Review
- Review
- Development and validation of a novel risk classification tool for predicting long length of stay in NICU blood transfusion infants.Scientific reports · 2024Article
- Neuromonitoring in neonatal critical care part II: extremely premature infants and critically ill neonates.Pediatric research · 2023Review
- The short-term effects of RBC transfusions on intestinal injury in preterm infants.Pediatric research · 2023Article
- Renal versus cerebral saturation trajectories: the perinatal transition in preterm neonates.Pediatric research · 2022Article
- Association of Bolus Feeding With Splanchnic and Cerebral Oxygen Utilization Efficiency Among Premature Infants With Anemia and After Blood Transfusion.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study investigated the ability of near-infrared spectroscopy (NIRS) to detect subgroups of preterm infants who benefit most from red blood cell (RBC) transfusion in regard to cerebral/renal tissue oxygenation (i) and the number of general oxygen desaturation below 80% (SaO(2) <80%) (ii). STUDY
designCerebral regional (crSO(2)) and peripheral regional (prSO(2)) NIRS parameters were recorded before, during, immediately after and 24 h after transfusion in 76 infants. Simultaneously, SaO(2) <80% were recorded by pulse oximetry. To answer the basic question of the study, all preterm infants were divided into two subgroups according to their pretransfusion crSO(2) values (<55% and ≥55%). This cutoff was determined by a k-means clustering analysis.
resultcrSO(2) and prSO(2) increased significantly in the whole study population. A stronger increase (P<0.0005) of both was found in the subgroup with pretransfusion crSO(2) values <55%. Regarding the whole population, a significant decrease (P<0.05) of episodes with SaO(2) <80% was observed. The subgroup with crSO(2) baselines <55% had significant (P<0.05) more episodes with SaO(2) <80% before transfusion. During and after transfusion, the frequency of episodes with SaO(2) <80% decreased more in this group compared with the group with crSO(2) baselines ≥55%.
conclusionNIRS measurement is a simple, non-invasive method to monitor regional tissue oxygenation and the efficacy of RBC transfusion. Infants with low initial NIRS values benefited most from blood transfusions regarding SaO(2) <80%, which may be important for their general outcome.
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Registered trials
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