ArticleCell cycle (Georgetown, Tex.)2012
Identification of an estrogen-regulated circadian mechanism necessary for breast acinar morphogenesis.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Associations between estradiol levels and subjective sleep parameters in a large cohort of men and women.Endocrine connections · 2026Article
- The Mouse Estrus and Circadian Cycles Interact to Influence Behavioral Rhythms: Relevance to the Menstrual Cycle in Humans.Journal of biological rhythms · 2025Article
- In Vitro Screening of Trehalose Synbiotics and Their Effects on Early-Lactating Females and Offspring Mice.Antioxidants (Basel, Switzerland) · 2024Article
- The Estrous Cycle Coordinates the Circadian Rhythm of Eating Behavior in Mice.Journal of biological rhythms · 2024Article
- Circadian rhythms and breast cancer: from molecular level to therapeutic advancements.Journal of cancer research and clinical oncology · 2024Review
- A time for sex: circadian regulation of mammalian sexual and reproductive function.Frontiers in neuroscience · 2024Review
- Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis.Cancer cell international · 2023Article
- Article
- Obesity, cancer risk, and time-restricted eating.Cancer metastasis reviews · 2022Review
- Estrogens and the circadian system.Seminars in cell & developmental biology · 2022Review
- Article
- Circadian rhythm disorder: a potential inducer of vascular calcification?Journal of physiology and biochemistry · 2020Review
- Review
- MYC-Associated Factor MAX is a Regulator of the Circadian Clock.International journal of molecular sciences · 2020Article
- High-Fat Diet Alters Circadian Rhythms in Mammary Glands of Pubertal Mice.Frontiers in endocrinology · 2020Article
- Circadian oscillations persist in low malignancy breast cancer cells.Cell cycle (Georgetown, Tex.) · 2019Article
- 3D Mammary Epithelial Cell Models: A Goldmine of DCIS Biomarkers and Morphogenetic Mechanisms.Cancers · 2019Article
- An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer.Frontiers in endocrinology · 2019Review
- Altered Circadian Rhythms and Breast Cancer: From the Human to the Molecular Level.Frontiers in endocrinology · 2018Review
- The sweet tooth of the circadian clock.Biochemical Society transactions · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Altered estrogen receptor α (ERA) signaling and altered circadian rhythms are both features of breast cancer. By using a method to entrain circadian oscillations in human cultured cells, we recently reported that the expression of key clock genes oscillates in a circadian fashion in ERA-positive breast epithelial cells but not in breast cancer cells, regardless of their ERA status. Moreover, we reported that ERA mRNA oscillates in a circadian fashion in ERA-positive breast epithelial cells, but not in ERA-positive breast cancer cells. By using ERA-positive HME1 breast epithelial cells, which can be both entrained in vitro and can form mammary gland-like acinar structures in three-dimensional (3D) culture, first we identified a circuit encompassing ERA and an estrogen-regulated loop consisting of two circadian clock genes, PER2 and BMAL1. Further, we demonstrated that this estrogen-regulated circuit is necessary for breast epithelial acinar morphogenesis. Disruption of this circuit due to ERA-knockdown, negatively affects the estrogen-sustained circadian PER2-BMAL1 mechanism as well as the formation of 3D HME1 acini. Conversely, knockdown of either PER2 or BMAL1, by hampering the PER2-BMAL1 loop of the circadian clock, negatively affects ERA circadian oscillations and 3D breast acinar morphogenesis. To our knowledge, this study provides the first evidence of the implication of an ERA-circadian clock mechanism in the breast acinar morphogenetic process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.