ReviewJournal of cell science2012
Actin nucleators in the nucleus: an emerging theme.
Review in Journal of cell science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Article
- Method for Analyzing Nucleoskeletal Components from the Isolated Nucleus.Methods in molecular biology (Clifton, N.J.) · 2026Article
- mDia formins form hetero-oligomers and cooperatively maintain murine hematopoiesis.PLoS genetics · 2023Article
- Article
- Proteomic Markers for Mechanobiological Properties of Metastatic Cancer Cells.International journal of molecular sciences · 2023Review
- A Multisensory Network Drives Nuclear Mechanoadaptation.Biomolecules · 2022Review
- Review
- Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis.Frontiers in cell and developmental biology · 2021Review
- Assembling nuclear domains: Lessons from DNA repair.The Journal of cell biology · 2019Review
- Functions of nuclear actin-binding proteins in human cancer.Oncology letters · 2018Article
- Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.Nucleic acids research · 2017Article
- Regulation of actin nucleation and autophagosome formation.Cellular and molecular life sciences : CMLS · 2016Review
- Actin, actin-binding proteins, and actin-related proteins in the nucleus.Histochemistry and cell biology · 2016Review
- Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter.PloS one · 2016Article
- Nucleolus-like body of mouse oocytes contains lamin A and B and TRF2 but not actin and topo II.Molecular cytogenetics · 2016Article
- piggyBac insertional mutagenesis screen identifies a role for nuclear RHOA in human ES cell differentiation.Stem cell reports · 2015Article
- Nuclear F-actin formation and reorganization upon cell spreading.The Journal of biological chemistry · 2015Article
- The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer.International journal of molecular sciences · 2015Review
- To be or not to be assembled: progressing into nuclear actin filaments.Nature reviews. Molecular cell biology · 2013Review
- Arp2/3-mediated actin-based motility: a tail of pathogen abuse.Cell host & microbe · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Actin is an integral component of the cytoskeleton, forming a plethora of macromolecular structures that mediate various cellular functions. The formation of such structures relies on the ability of actin monomers to associate into polymers, and this process is regulated by actin nucleation factors. These factors use monomeric actin pools at specific cellular locations, thereby permitting rapid actin filament formation when required. It has now been established that actin is also present in the nucleus, where it is implicated in chromatin remodelling and the regulation of eukaryotic gene transcription. Notably, the presence of typical actin filaments in the nucleus has not been demonstrated directly. However, studies in recent years have provided evidence for the nuclear localisation of actin nucleation factors that promote cytoplasmic actin polymerisation. Their localisation to the nucleus suggests that these proteins mediate collaboration between the cytoskeleton and the nucleus, which might be dependent on their ability to promote actin polymerisation. The nature of this cooperation remains enigmatic and it will be important to elucidate the physiological relevance of the link between cytoskeletal actin networks and nuclear events. This Commentary explores the current evidence for the nuclear roles of actin nucleation factors. Furthermore, the implication of actin-associated proteins in relaying exogenous signals to the nucleus, particularly in response to cellular stress, will be considered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.