ArticleCell death and differentiation2013
Identification of factors that function in Drosophila salivary gland cell death during development using proteomics.
Article in Cell death and differentiation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Independent roles of autophagy and apoptosis in post-apocrine-secretion cell death of salivary glands during Drosophila metamorphosis.Scientific reports · 2026Article
- Nacα protects the larval fat body from cell death by maintaining cellular proteostasis in Drosophila.Nature communications · 2023Article
- Cp1/cathepsin L is required for autolysosomal clearance inAutophagy · 2021Article
- Thioredoxin-80 protects against amyloid-beta pathology through autophagic-lysosomal pathway regulation.Molecular psychiatry · 2021Article
- I Spy in the Developing Fly a Multitude of Ways to Die.Journal of developmental biology · 2018Review
- Life, death and autophagy.Nature cell biology · 2018Review
- Mutants forG3 (Bethesda, Md.) · 2017Article
- Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila.BMC cell biology · 2013Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Proteasome inhibitors induce cell death and are used in cancer therapy, but little is known about the relationship between proteasome impairment and cell death under normal physiological conditions. Here, we investigate the relationship between proteasome function and larval salivary gland cell death during development in Drosophila. Drosophila larval salivary gland cells undergo synchronized programmed cell death requiring both caspases and autophagy (Atg) genes during development. Here, we show that ubiquitin proteasome system (UPS) function is reduced during normal salivary gland cell death, and that ectopic proteasome impairment in salivary gland cells leads to early DNA fragmentation and salivary gland condensation in vivo. Shotgun proteomic analyses of purified dying salivary glands identified the UPS as the top category of proteins enriched, suggesting a possible compensatory induction of these factors to maintain proteolysis during cell death. We compared the proteome following ectopic proteasome impairment to the proteome during developmental cell death in salivary gland cells. Proteins that were enriched in both populations of cells were screened for their function in salivary gland degradation using RNAi knockdown. We identified several factors, including trol, a novel gene CG11880, and the cop9 signalsome component cop9 signalsome 6, as required for Drosophila larval salivary gland degradation.
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