ArticleMechanisms of ageing and development
Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle.
Article in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Mitochondrial diagnostics reveal diffuse impairments in skeletal muscle energetics in aging mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Mitochondrial efficiency in resting skeletal muscle in vivo: a novel non-invasive approach using multinuclear magnetic resonance spectroscopy in humans.The Journal of physiology · 2025Article
- Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.The Journal of physiology · 2025Article
- Mitochondrial free radicals contribute to cigarette smoke condensate-induced impairment of oxidative phosphorylation in the skeletal muscle in situ.Free radical biology & medicine · 2024Article
- Real-time assessment of relative mitochondrial ATP synthesis response against inhibiting and stimulating substrates (MitoRAISE).Cancer & metabolism · 2024Article
- MyD88 deficiency ameliorates weight loss caused by intestinal oxidative injury in an autophagy-dependent mechanism.Journal of cachexia, sarcopenia and muscle · 2022Article
- Targeting the Mitochondria in Heart Failure: A Translational Perspective.JACC. Basic to translational science · 2020Review
- Lower Central Fat Increase Risk of One-Year Muscle Mass Loss in Menopausal Women.Mediators of inflammation · 2020Article
- Mathematical absurdities in the California net energy system.Translational animal science · 2019Article
- Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.Free radical biology & medicine · 2019Article
- Energetic efficiency and the first law: the California net energy system revisited.Journal of animal science · 2018Article
- Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms.Antioxidants & redox signaling · 2017Review
- Exercise and CKD: Skeletal Muscle Dysfunction and Practical Application of Exercise to Prevent and Treat Physical Impairments in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Review
- Skeletal muscle bioenergetics in aging and heart failure.Heart failure reviews · 2017Review
- Article
- NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.Science translational medicine · 2016Article
- Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods.Biochimica et biophysica acta · 2016Review
- Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.Aging cell · 2016Article
- Mitochondria to motion: optimizing oxidative phosphorylation to improve exercise performance.The Journal of experimental biology · 2016Review
- The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function.Frontiers in physiology · 2015Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Periods of elevated reactive oxygen species (ROS) production are a normal part of mitochondrial physiology. However, little is known about age-related changes in the mitochondrial response to elevated ROS in vivo. Significantly, ROS-induced uncoupling of oxidative phosphorylation has received attention as a negative feedback mechanism to reduce mitochondrial superoxide production. Here we use a novel in vivo spectroscopy system to test the hypothesis that ROS-induced uncoupling is diminished in aged mitochondria. This system simultaneously acquires (31)P magnetic resonance and near-infrared optical spectra to non-invasively measure phosphometabolite and O(2) concentrations in mouse skeletal muscle. Using low dose paraquat to elevate intracellular ROS we assess in vivo mitochondrial function in young, middle aged, and old mice. Oxidative phosphorylation was uncoupled to the same degree in response to ROS at each age, but this uncoupling was associated with loss of phosphorylation capacity and total ATP in old mice only. Using mice lacking UCP3 we demonstrate that this in vivo uncoupling is independent of this putative uncoupler of skeletal muscle mitochondria. These data indicate that ROS-induced uncoupling persists throughout life, but that oxidative stress leads to mitochondrial deficits and loss of ATP in aged organisms that may contribute to impaired function and degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.