ArticleThe British journal of nutrition2013
Antioxidant status and its association with elevated depressive symptoms among US adults: National Health and Nutrition Examination Surveys 2005-6.
Article in The British journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Associations of Dietary Vitamin A and Beta-Carotene Intake With Depression. A Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2019Trial
- Trial
- Association among obesity, insulin resistance, and depressive symptoms: a mediation analysis.BMC psychiatry · 2025Article
- Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion.iScience · 2023Article
- Dietary niacin intake in relation to depression among adults: a population-based study.BMC psychiatry · 2023Article
- Relationship between Serum Selenium Level and Self-Reported History of Kidney Stone.Nutrients · 2023Article
- Article
- Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview.Antioxidants (Basel, Switzerland) · 2023Review
- Dietary Intake of Carotenoids and Risk of Depressive Symptoms: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- The Relationship between FAntioxidants (Basel, Switzerland) · 2022Article
- Dietary antioxidants and fibre intake and depressive symptoms in Iranian adolescent girls.Public health nutrition · 2021Article
- Nutrient patterns and depressive symptoms among Australian adults.European journal of nutrition · 2021Article
- The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project.European journal of nutrition · 2021Article
- Sex and age differences in the associations between sleep behaviors and all-cause mortality in older adults: results from the National Health and Nutrition Examination Surveys.Sleep medicine · 2017Article
- Nutrition and Lifestyle Intervention on Mood and Neurological Disorders.Journal of evidence-based complementary & alternative medicine · 2017Article
- Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study.Translational psychiatry · 2016Article
- Article
- Gene polymorphisms and gene scores linked to low serum carotenoid status and their associations with metabolic disturbance and depressive symptoms in African-American adults.The British journal of nutrition · 2014Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
We examined the relationship of elevated depressive symptoms with antioxidant status. Cross-sectional data from the National Health and Nutrition Examination Surveys 2005–6 on US adults aged 20–85 years were analysed. Depressive symptoms were measured using the Patient Health Questionnaire with a score cut-off point of 10 to define ‘elevated depressive symptoms’. Serum antioxidant status was measured by serum levels of carotenoids, retinol (free and retinyl esters), vitamin C and vitamin E. The main analyses consisted of multiple logistic and zero-inflated Poisson regression models, taking into account sampling design complexity. The final sample consisted of 1798 US adults with complete data. A higher total serum carotenoid level was associated with a lower likelihood of elevated depressive symptoms with a reduction in the odds by 37 % overall with each sd increase in exposure, and by 34 % among women (P< 0·05). A dose–response relationship was observed when total serum carotenoids were expressed as quartiles (Q4 (1·62–10·1 μmol/l) v. Q1 (0·06–0·86 μmol/l): OR 0·41; 95 % CI 0·23, 0·76, P< 0·001; P for trend = 0·035), though no significant associations were found with the other antioxidant levels. Among carotenoids, β-carotene (men and women combined) and lutein+zeaxanthins (women only, after control for dietary lutein+zeaxanthin intake and supplement use) had an independent inverse association with elevated depressive symptoms among US adults. None of the other serum antioxidants had a significant association with depressive symptoms, independently of total carotenoids and other covariates. In conclusion, total carotenoids (mainly β-carotene and lutein+zeaxanthins) in serum were associated with reduced levels of depressive symptoms among community-dwelling US adults.
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