ArticleJournal of periodontal research2013
Loss of dentin sialophosphoprotein leads to periodontal diseases in mice.
Article in Journal of periodontal research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts.International journal of molecular sciences · 2026Article
- Long-term haplodeficency of DSPP causes temporomandibular joint osteoarthritis in mice.BMC oral health · 2024Article
- Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering.Calcified tissue international · 2023Review
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Effects ofGlobal medical genetics · 2021Review
- [Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Review
- Dentin Sialophosphoprotein Deletion Leads to Femoral Head Cartilage Attenuation and Subchondral Bone Ill-mineralization.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Haploinsufficiency ofFrontiers in physiology · 2020Article
- Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown.Journal of dental research · 2019Article
- Dentinogenesis and Tooth-Alveolar Bone Complex Defects inStem cells and development · 2019Article
- Compromised alveolar bone cells in a patient with dentinogenesis imperfecta caused by DSPP mutation.Clinical oral investigations · 2019Article
- The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein.International journal of oral science · 2018Review
- Twist1 Suppresses Cementoblast Differentiation.Dentistry journal · 2018Article
- Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.Bone · 2017Article
- Periodontal disease and FAM20A mutations.Journal of human genetics · 2017Article
- Genes Critical for Developing Periodontitis: Lessons from Mouse Models.Frontiers in immunology · 2017Review
- Repair of dentin defects from DSPP knockout mice by PILP mineralization.Journal of materials research · 2016Article
- Follicle-stimulating hormone enhances alveolar bone resorption via upregulation of cyclooxygenase-2.American journal of translational research · 2016Article
- Article
- Overexpressing the NHJournal of oral biosciences · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveDentin sialophosphoprotein (DSPP) and its cleaved products, dentin phosphoprotein (DPP) and dentin sialoprotein (DSP), play important roles in biomineralization. Recently, we observed that DSPP is highly expressed in the alveolar bone and cementum, indicating that this molecule may play an important role in the formation and maintenance of a healthy periodontium, and its deletion may cause increased susceptibility to periodontal diseases. The objective of this investigation was to study the effects of Dspp ablation on periodontal tissues by analyzing Dspp null mice. MATERIAL AND
methodsNewborn to 6-mo-old Dspp null mice were examined, and the 3- and 6-mo-old Dspp null mice were characterized in detail using X-ray radiography, histology and scanning electron microscopy (backscattered as well as resin-infiltrating). Wild-type mice of the same age groups served as the normal controls.
resultsThe Dspp null mice showed significant loss of alveolar bone and cementum, particularly in the furcation and interproximal regions of the molars. The alveolar bone appeared porous while the quantity of cementum was reduced in the apical region. The canalicular systems and osteocytes in the alveolar bone were abnormal, with reduced numbers of canaliculi and altered osteocyte morphology. The loss of alveolar bone and cementum along with the detachment of the periodontal ligaments (PDL) led to the apical migration of the epithelial attachment and formation of periodontal pockets.
conclusionInactivation of DSPP leads to the loss of alveolar bone and cementum and increased susceptibility to bacterial infections in PDL of Dspp null mice. The fact that the loss of DSPP results in periodontal diseases indicates that this molecule plays a vital role in maintaining the health of the periodontium.
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Registered trials
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