Evidence map›Paper›PMID 22934133›Full record

ArticleScientific reports2012

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells.

Chia-Chi Chien, Hsiang-Hsin Chen, Sheng-Feng Lai, Y Hwu, Cyril Petibois, C S Yang, Y Chu, G Margaritondo

Abstract read
In one paragraph

Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
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  8. Article
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  10. Article
  11. Article
  12. Systematic in vitro toxicological screening of gold nanoparticles designed for nanomedicine applications.Toxicology in vitro : an international journal published in association with BIBRA · 2015
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chia-Chi ChienInstitute of Physics, Academia Sinica, Nankang, Taipei 115, Taiwan.
Hsiang-Hsin Chen
Sheng-Feng Lai
Y Hwu
Cyril Petibois
C S Yang
Y Chu
G Margaritondo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.

Indexed as

GoldMetal NanoparticlesAnimalsCell Line, TumorCell TrackingMiceMice, Inbred BALB CNeoplasmsRadiographyGold

Identifiers

PMID22934133
PMCPMC3429882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.