ArticleInternational journal of microbiology2012
Gut microbial translocation in critically ill children and effects of supplementation with pre- and pro biotics.
Article in International journal of microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Prebiotic potential of oligosaccharides extracted from improved Ugandan varieties of millet, sesame, soybean, and sorghum: enhancing probiotic growth and enteric pathogen inhibition.BMC microbiology · 2025Article
- Emergence ofAfrican journal of medicine and medical sciences · 2023Article
- Parvovirus enteritis and other risk factors associated with persistent gastrointestinal signs in dogs later in life: a retrospective cohort study.BMC veterinary research · 2022Article
- Oral Bacteriotherapy Reduces the Occurrence of Chronic Fatigue in COVID-19 Patients.Frontiers in nutrition · 2021Article
- Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway.Innate immunity · 2020Article
- Constructing personalized longitudinal holo'omes of colon cancer-prone humans and their modeling in flies and mice.Oncotarget · 2019Article
- (1→3)-β-d-Glucan: A Biomarker for Microbial Translocation in Individuals with Acute or Early HIV Infection?Frontiers in immunology · 2016Article
- Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation.Mucosal immunology · 2014Article
- Role of Ankaferd on bacterial translocation and inflammatory response in an experimental rat model of intestinal obstruction.International journal of clinical and experimental medicine · 2014Article
- A pilot study of Bifidobacterium breve in neonates undergoing surgery for congenital heart disease.Journal of intensive care · 2014Article
- Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer.Frontiers in cellular and infection microbiology · 2014Review
- Bacterial colonization and intestinal mucosal barrier development.World journal of clinical pediatrics · 2013Review
- Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis.Journal of theoretical biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome. Critically ill children are at increased risk for bacterial translocation, particularly in the early postnatal age. Predisposing factors include intestinal obstruction, obstructive jaundice, intra-abdominal hypertension, intestinal ischemia/reperfusion injury and secondary ileus, and immaturity of the intestinal barrier per se. Despite good evidence from experimental studies to support the theory of bacterial translocation as a cause of sepsis, there is little evidence in human studies to confirm that translocation is directly correlated to bloodstream infections in critically ill children. This paper provides an overview of the gut microflora and its significance, a focus on the mechanisms employed by bacteria to gain access to the systemic circulation, and how critical illness creates a hostile environment in the gut and alters the microflora favoring the growth of pathogens that promote bacterial translocation. It also covers treatment with pre- and pro biotics during critical illness to restore the balance of microbial communities in a beneficial way with positive effects on intestinal permeability and bacterial translocation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.