ArticleFrontiers in physiology2012
Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
- MiRNA delivery systems in cancer stem cell therapy: exosomes versus chitosan nanoparticles.Stem cell research & therapy · 2025Review
- Stimulative piezoelectric nanofibrous scaffolds for enhanced small extracellular vesicle production in 3D cultures.Biomaterials science · 2024Article
- Influence of Chitosan on the Viability of Encapsulated and Dehydrated Formulations of Vegetative Cells of Actinomycetes.Polymers · 2024Article
- TurningBiomedicines · 2024Article
- Chitosan-insulin nano-formulations as critical modulators of inflammatory cytokines and Nrf-2 pathway to accelerate burn wound healing.Discover nano · 2023Article
- Polymeric nanoparticles for DNA vaccine-based cancer immunotherapy: a review.Biotechnology letters · 2023Review
- Antibacterial nanocomposite of chitosan/silver nanocrystals/graphene oxide (ChAgG) development for its potential use in bioactive wound dressings.Scientific reports · 2023Article
- pH-driven continuous stem cell production with enhanced regenerative capacity from polyamide/chitosan surfaces.Materials today. Bio · 2023Article
- Biocompatibility of Chitosan Nanoparticle in Root Canal Sealant with Vero Cell Line.International journal of clinical pediatric dentistry · 2022Article
- Cannabidiol-Loaded Mixed Polymeric Micelles of Chitosan/Poly(Vinyl Alcohol) and Poly(Methyl Methacrylate) for Trans-Corneal Delivery.Pharmaceutics · 2021Article
- Hybrid Hierarchical Heterostructures of Nanoceramic Phosphors as Imaging Agents for Multiplexing and Living Cancer Cells Translocation.ACS applied bio materials · 2021Article
- Biofabrication of chitosan/chitosan nanoparticles/polycaprolactone transparent membrane for corneal endothelial tissue engineering.Scientific reports · 2021Article
- Fabrication of nanochitosan incorporated polypyrrole/alginate conducting scaffold for neural tissue engineering.Scientific reports · 2020Article
- The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells.Polymers · 2018Article
- Highly photostable nanogels for fluorescence-based theranostics.Bioactive materials · 2018Article
- Advances in keratinocyte delivery in burn wound care.Advanced drug delivery reviews · 2018Review
- Carbohydrates-chitosan composite carrier for Vero cell culture.Cytotechnology · 2016Article
- Polymeric nanoparticles: potent vectors for vaccine delivery targeting cancer and infectious diseases.Human vaccines & immunotherapeutics · 2014Review
- Application of ferriferous oxide modified by chitosan in gene delivery.Journal of drug delivery · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a biomaterial, chitosan has been widely used in tissue engineering, wound healing, drug delivery, and other biomedical applications. It can be formulated in a variety of forms, such as powder, film, sphere, gel, and fiber. These features make chitosan an almost ideal biomaterial in cell culture applications, and cell cultures arguably constitute the most practical way to evaluate biocompatibility and biotoxicity. The advantages of cell cultures are that they can be performed under totally controlled environments, allow high throughput functional screening, and are less costly, as compared to other assessment methods. Chitosan can also be modified into multilayer composite by combining with other polymers and moieties to alter the properties of chitosan for particular biomedical applications. This review briefly depicts and discusses applications of chitosan and nanoparticles in cell culture, in particular, the effects of chitosan and nanoparticles on cell adhesion, cell survival, and the underlying molecular mechanisms: both stimulatory and inhibitory influences are discussed. Our aim is to update the current status of how nanoparticles can be utilized to modify the properties of chitosan to advance the art of tissue engineering by using cell cultures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.