ArticleFrontiers in physiology2012
Sympathetic regulation of vascular function in health and disease.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 108 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect Of Postural Reprogramming Insoles In Regulating Blood Pressure, Posture And Quality Of Life In Hypertensive Subjects
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease
Who cites it
108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- The Diagnostic Value of ECG Characteristics for Vasospastic and Microvascular Angina: A Systematic Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Pooled it
- Effects of sleep deprivation on endothelial function in adult humans: a systematic review.GeroScience · 2021Pooled it
- Short-term cocoa bioflavanol supplementation does not improve cold-induced vasodilation in young healthy adults.European journal of applied physiology · 2024Trial
- Moderate dose of dietary nitrate improves skeletal muscle microvascular function in patients with peripheral artery disease.Microvascular research · 2023Trial
- Trial
- 14-Day Ketone Supplementation Lowers Glucose and Improves Vascular Function in Obesity: A Randomized Crossover Trial.The Journal of clinical endocrinology and metabolism · 2021Trial
- The Effects of a Simulated Workday of Prolonged Sitting on Seated versus Supine Blood Pressure and Pulse Wave Velocity in Adults with Overweight/Obesity and Elevated Blood Pressure.Journal of vascular research · 2020Trial
- Heart rate variability during hemodialysis is an indicator for long-term vascular access survival in uremic patients.PloS one · 2017Trial
- Asymmetric and Symmetric Dimethylarginine and Sympathetic Nerve Traffic after Renal Denervation in Patients with Resistant Hypertension.Clinical journal of the American Society of Nephrology : CJASN · 2015Trial
- Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation.The Journal of physiology · 2014Trial
- Autonomic cardiovascular changes during reactive hyperemia.Clinical physiology and functional imaging · 2026Article
- Three-dimensional mapping and functional analysis of sympathetic innervation in aortic perivascular adipose tissue.Life metabolism · 2026Article
- Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post-traumatic stress disorder.Experimental physiology · 2026Article
- Artery-Like Smooth Muscle Drives Contractile Function in Dural Venous Sinuses.bioRxiv : the preprint server for biology · 2026Article
- Comparative effects of regular, bloomed or white chocolate on cardiovascular and antioxidant markers in healthy adults.Metabolism open · 2026Article
- Interaction between white coat effect and hypertension on arterial stiffness.Journal of hypertension · 2026Article
- Deep Vein Thrombosis Prevention in Acute Ischemic Stroke Patients with Lower Limb Paralysis: A Narrative Review.Journal of clinical medicine · 2026Review
- The association between extracellular fluid volume and sympathetic nervous system activity in patients with chronic kidney disease.American journal of physiology. Renal physiology · 2026Article
- Impact of apparent temperature on specific cardiovascular disease admissions: a time-series study and association modification in Xiangyang, China.BMC public health · 2025Article
- Assessing cardiac function in obstructive sleep apnea using a novel metric: integrating the respiratory event frequency and desaturation duration.BMC pulmonary medicine · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sympathetic nervous system (SNS) is known to play a pivotal role in short- and long-term regulation of different functions of the cardiovascular system. In the past decades increasing evidence demonstrated that sympathetic neural control is involved not only in the vasomotor control of small resistance arteries but also in modulation of large artery function. Sympathetic activity and vascular function, both of which are key factors in the development and prognosis of cardiovascular events and disease, are linked at several levels. Evidence from experimental studies indicates that the SNS is critically influenced, at the central and also at the peripheral level, by the most relevant factors regulating vascular function, such as nitric oxide (NO), reactive oxygen species (ROS), endothelin (ET), the renin-angiotensin system. Additionally, there is indirect evidence of a reciprocal relationship between endothelial function and activity of the SNS. A number of cardiovascular risk factors and diseases are characterized both by increased sympathetic outflow and decreased endothelial function. In healthy subjects, muscle sympathetic nerve activity (MSNA) appears to be related to surrogate markers of endothelial function, and an acute increase in sympathetic activity has been associated with a decrease in endothelial function in healthy subjects. However, direct evidence of a cause-effect relationship from human studies is scanty. In humans large artery stiffness has been associated with increased sympathetic discharge, both in healthy subjects and in renal transplant recipients. Peripheral sympathetic discharge is also able to modulate wave reflection. On the other hand, large artery stiffness can interfere with autonomic regulation by impairing carotid baroreflex sensitivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.