ArticleFrontiers in physiology2012
A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Modeling insights into potential mechanisms of opioid-induced respiratory depression within medullary and pontine networks.Journal of neurophysiology · 2026Article
- In-silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach.PLoS computational biology · 2024Article
- Respiratory entrainment of the locus coeruleus modulates arousal level to avoid physical risks from external vibration.Scientific reports · 2023Article
- Fentanyl effects on respiratory neuron activity in the dorsolateral pons.Journal of neurophysiology · 2022Article
- Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.Journal of neurophysiology · 2021Review
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model.Journal of neurophysiology · 2017Article
- Microinjection of kynurenic acid in the rostral nucleus of the tractus solitarius disrupts spatiotemporal aspects of mechanically induced tracheobronchial cough.Journal of neurophysiology · 2017Article
- Computational models of the neural control of breathing.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Cough modulation by upper airway stimuli in cat - potential clinical application?Open journal of molecular and integrative physiology · 2016Article
- Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Role of the dorsal medulla in the neurogenesis of airway protection.Pulmonary pharmacology & therapeutics · 2015Review
- Peripheral neural circuitry in cough.Current opinion in pharmacology · 2015Review
- Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network.Journal of neurophysiology · 2015Article
- Review
- Review
- A closed-loop model of the respiratory system: focus on hypercapnia and active expiration.PloS one · 2014Article
- Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders.Frontiers in physiology · 2014Article
- Resuscitation and auto resuscitation by airway reflexes in animals.Cough (London, England) · 2013Article
- Motor circuit-specific burst patterns drive different muscle and behavior patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Data-driven computational neural network models have been used to study mechanisms for generating the motor patterns for breathing and breathing related behaviors such as coughing. These models have commonly been evaluated in open loop conditions or with feedback of lung volume simply represented as a filtered version of phrenic motor output. Limitations of these approaches preclude assessment of the influence of mechanical properties of the musculoskeletal system and motivated development of a biomechanical model of the respiratory muscles, airway, and lungs using published measures from human subjects. Here we describe the model and some aspects of its behavior when linked to a computational brainstem respiratory network model for breathing and airway defensive behavior composed of discrete "integrate and fire" populations. The network incorporated multiple circuit paths and operations for tuning inspiratory drive suggested by prior work. Results from neuromechanical system simulations included generation of a eupneic-like breathing pattern and the observation that increased respiratory drive and operating volume result in higher peak flow rates during cough, even when the expiratory drive is unchanged, or when the expiratory abdominal pressure is unchanged. Sequential elimination of the model's sources of inspiratory drive during cough also suggested a role for disinhibitory regulation via tonic expiratory neurons, a result that was subsequently supported by an analysis of in vivo data. Comparisons with antecedent models, discrepancies with experimental results, and some model limitations are noted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.