ArticleFrontiers in physiology2012
Dendritic Signaling in Inhibitory Interneurons: Local Tuning via Group I Metabotropic Glutamate Receptors.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Input-Specific Synaptic Location and Function of the α5 GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Calcium Dynamics in Dendrites of Hippocampal CA1 Interneurons in Awake Mice.Frontiers in cellular neuroscience · 2019Article
- Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons.Neuropharmacology · 2018Article
- Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices.Journal of visualized experiments : JoVE · 2018Article
- Plasticity in Single Axon Glutamatergic Connection to GABAergic Interneurons Regulates Complex Events in the Human Neocortex.PLoS biology · 2016Article
- Article
- Molecular mechanisms of dendrite morphogenesis.Frontiers in cellular neuroscience · 2012Article
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Authors and funding
3 authors.
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Abstract
Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic signals. For example, peri- and extra-synaptic signaling through the group I metabotropic glutamate receptors (mGluRs) can be involved in the highly compartmentalized regulation of dendritic ion conductances, the induction of input-specific synaptic plasticity, and the local release of retrograde messengers. Therefore, extrasynaptic mechanisms appear to play a key role in the local tuning of dendritic computations. Here, we review recent findings on the role of group I mGluRs in the dendritic signaling of inhibitory interneurons. We propose that group I mGluRs provide a dual-mode signaling device that integrates different patterns of neural activity. By implementing distinct forms of intrinsic and synaptic regulation, group I mGluRs may be responsible for the local fine-tuning of dendritic function.
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