ArticleMolecular vision2012
Aqueous humor concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in high myopic patients.
Article in Molecular vision, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Biological mechanisms of atropine in myopia control (Review).Molecular medicine reports · 2026Pooled it
- Aqueous Humour Cytokines as Predictors of Axial Elongation in High Myopia: A 2-Year Longitudinal Cohort Study.Clinical & experimental ophthalmology · 2026Observational
- Comparison of trabeculectomy and gonioscopy-assisted transluminal trabeculotomy results in long eyes wıth open-angle glaucoma.International ophthalmology · 2025Article
- Hypoxia and growth factor profiling in high myopia: linking HIF-1α suppression and PDGF-BB activation to structural degeneration.Frontiers in medicine · 2025Article
- Retinal nerve fiber layer thickness and radial peripapillary capillaries density in myopic adults with optical coherence tomography angiography.BMC ophthalmology · 2024Article
- Effect of magnification error and axial length on circumpapillary capillary density and retinal nerve fiber layer thickness.Scientific reports · 2024Article
- Innate immune responsive inflammation in development of progressive myopia.Eye (London, England) · 2024Article
- Aqueous humor protein markers in myopia: a review.International ophthalmology · 2024Review
- Molecular changes in intraocular fluid: implications for myopia.International journal of biological sciences · 2024Review
- Prevalence of retinal pathologies in people over 60 years: the Tehran Geriatrics Eye Study.International journal of ophthalmology · 2024Article
- Structural, blood flow and functional changes in the macular area and the expression of aqueous humor factors in myopia.Frontiers in medicine · 2024Article
- Biomarker Signature in Aqueous Humor Mirrors Lens Epithelial Cell Activation: New Biomolecular Aspects from Cataractogenic Myopia.Biomolecules · 2023Article
- High VEGF Concentrations Accelerate Human Trabecular Meshwork Fibrosis in a TAZ-Dependent Manner.International journal of molecular sciences · 2023Article
- Alterations in the Choroidal Sublayers in Relationship to Severity and Progression of Diabetic Retinopathy: A Swept-Source OCT Study.Ophthalmology science · 2022Article
- Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study.Frontiers in medicine · 2021Article
- Association of Myopia with Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetic Patients Without Diabetic Retinopathy.Investigative ophthalmology & visual science · 2020Article
- Imbalance Between Oxidative Stress and Growth Factors in Human High Myopia.Frontiers in physiology · 2020Article
- A negative correlation of axial length with aqueous humor concentration of cytokines in patients with congenital cataracts.Molecular vision · 2020Article
- The expression of cytokines in aqueous humor of high myopic patients with cataracts.Molecular vision · 2020Article
- Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization.Oxidative medicine and cellular longevity · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the aqueous humor levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in high myopic eyes and control eyes.
methodsAqueous humor samples were collected from 21 highly myopic eyes of 20 patients (high myopia group) and from 30 cataract eyes of 30 patients with no choroidal neovascularization (CNV) or other ocular or systemic diseases (control group). Of the 21 high myopic eyes, 13 had no complications secondary to high myopia (high myopia with no complications group), 3 had posterior staphyloma (high myopia with staphyloma group), and 5 had chorioretinal atrophy (high myopia with chorioretinal atrophy group). The aqueous humor levels of VEGF and PEDF were determined by using commercially available enzyme-linked immunosorbent assay kits.
resultsAqueous humor levels of VEGF were significantly lower in the high myopia group compared to that in the control group (p<0.001). VEGF levels decreased with an increase in the axial length (p<0.001). PEDF levels tended to be higher in the high myopia group compared to that in the control group; however, the difference was not significant. Three high myopia groups had significantly lower VEGF/PEDF ratios than the control group (p=0.000, 0.002, and 0.005).
conclusionsAqueous humor levels of VEGF in the high myopia group were significantly lower than those in the control group. The differing levels of VEGF and PEDF in the high myopia and control groups suggest that high myopia disrupts the VEGF/PEDF balance in retinal pigment epithelium (RPE) cells.
Indexed as
Identifiers
22933839PMC3429358W2159508545What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.