ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Article
- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation.Biology · 2024Article
- Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology.Channels (Austin, Tex.) · 2023Review
- Morpho-Electric Properties and Diversity of Oxytocin Neurons in Paraventricular Nucleus of Hypothalamus in Female and Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy.Epilepsy research · 2019Article
- The Augmentation of Retinogeniculate Communication during Thalamic Burst Mode.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics.Nature neuroscience · 2019Article
- A novel mutual information estimator to measure spike train correlations in a model thalamocortical network.Journal of neurophysiology · 2018Article
- T-type calcium channels in the orbitofrontal cortex mediate sensory integration as measured using a spontaneous oddity task in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures.Nature neuroscience · 2018Article
- Article
- Impact of Electrode Position on the Elicitation of Sodium Spikes in Retinal Bipolar Cells.Scientific reports · 2017Article
- The role of T-type calcium channels in the subiculum: to burst or not to burst?The Journal of physiology · 2017Article
- Multiplexed Spike Coding and Adaptation in the Thalamus.Cell reports · 2017Article
- Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- T-type calcium channels in synaptic plasticity.Channels (Austin, Tex.) · 2017Review
- Genetic Tracing of CaFrontiers in molecular neuroscience · 2017Article
- Cortex dynamically modulates responses of thalamic relay neurons through prolonged circuit-level disinhibition in rat thalamus in vivo.Journal of neurophysiology · 2016Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The thalamic output during different behavioral states is strictly controlled by the firing modes of thalamocortical neurons. During sleep, their hyperpolarized membrane potential allows activation of the T-type calcium channels, promoting rhythmic high-frequency burst firing that reduces sensory information transfer. In contrast, in the waking state thalamic neurons mostly exhibit action potentials at low frequency (i.e., tonic firing), enabling the reliable transfer of incoming sensory inputs to cortex. Because of their nearly complete inactivation at the depolarized potentials that are experienced during the wake state, T-channels are not believed to modulate tonic action potential discharges. Here, we demonstrate using mice brain slices that activation of T-channels in thalamocortical neurons maintained in the depolarized/wake-like state is critical for the reliable expression of tonic firing, securing their excitability over changes in membrane potential that occur in the depolarized state. Our results establish a novel mechanism for the integration of sensory information by thalamocortical neurons and point to an unexpected role for T-channels in the early stage of information processing.
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