ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Coding rate and duration of vocalizations of the frog, Xenopus laevis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dynamic emotion fabric theory: a new framework for understanding the biology of flexible emotion states.Social cognitive and affective neuroscience · 2026Review
- Article
- Motoneuronal Regulation of Central Pattern Generator and Network Function.Advances in neurobiology · 2022Article
- Modular timer networks: abdominal interneurons controlling the chirp and pulse pattern in a cricket calling song.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Molecular characterization of frog vocal neurons using constellation pharmacology.Journal of neurophysiology · 2020Article
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Inspiring song: The role of respiratory circuitry in the evolution of vertebrate vocal behavior.Developmental neurobiology · 2020Review
- Feedback to the future: motor neuron contributions to central pattern generator function.The Journal of experimental biology · 2019Review
- Premotor Neuron Divergence Reflects Vocal Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inhibitory and modulatory inputs to the vocal central pattern generator of a teleost fish.The Journal of comparative neurology · 2018Article
- Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Probing forebrain to hindbrain circuit functions in Xenopus.Genesis (New York, N.Y. : 2000) · 2017Review
- Central pattern generator for vocalization: is there a vertebrate morphotype?Current opinion in neurobiology · 2014Review
- The Xenopus amygdala mediates socially appropriate vocal communication signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
2 authors.
Funding
Abstract
Vocalizations involve complex rhythmic motor patterns, but the underlying temporal coding mechanisms in the nervous system are poorly understood. Using a recently developed whole-brain preparation from which "fictive" vocalizations are readily elicited in vitro, we investigated the cellular basis of temporal complexity of African clawed frogs (Xenopus laevis). Male advertisement calls contain two alternating components--fast trills (∼300 ms) and slow trills (∼700 ms) that contain clicks repeated at ∼60 and ∼30 Hz, respectively. We found that males can alter the duration of fast trills without changing click rates. This finding led us to hypothesize that call rate and duration are regulated by independent mechanisms. We tested this by obtaining whole-cell patch-clamp recordings in the "fictively" calling isolated brain. We discovered a single type of premotor neuron with activity patterns correlated with both the rate and duration of fast trills. These "fast-trill neurons" (FTNs) exhibited long-lasting depolarizations (LLDs) correlated with each fast trill and action potentials that were phase-locked with motor output-neural correlates of call duration and rate, respectively. When depolarized without central pattern generator activation, FTNs produced subthreshold oscillations and action potentials at fast-trill rates, indicating FTN resonance properties are tuned to, and may dictate, the fast-trill rhythm. NMDA receptor (NMDAR) blockade eliminated LLDs in FTNs, and NMDAR activation in synaptically isolated FTNs induced repetitive LLDs. These results suggest FTNs contain an NMDAR-dependent mechanism that may regulate fast-trill duration. We conclude that a single premotor neuron population employs distinct mechanisms to regulate call rate and duration.
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