ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Identification of functional circuitry between retrosplenial and postrhinal cortices during fear conditioning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation.Molecular psychiatry · 2026Article
- Long-Term Memory Engrams From Development to Adulthood.Hippocampus · 2025Review
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
- Unique roles for the anterior and posterior retrosplenial cortices in encoding and retrieval of memory for context.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Postrhinal cortex contributions to the expression of auditory fear conditioning.Neurobiology of learning and memory · 2022Article
- Spatial context and the functional role of the postrhinal cortex.Neurobiology of learning and memory · 2022Review
- Distinct Contribution of Granular and Agranular Subdivisions of the Retrosplenial Cortex to Remote Contextual Fear Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory.Neurobiology of learning and memory · 2021Article
- Beyond the hippocampus: The role of parahippocampal-prefrontal communication in context-modulated behavior.Neurobiology of learning and memory · 2021Review
- Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance.Neuroscience and biobehavioral reviews · 2021Review
- The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner.Neurobiology of learning and memory · 2021Article
- The anterior retrosplenial cortex encodes event-related information and the posterior retrosplenial cortex encodes context-related information during memory formation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Retrosplenial Cortical Connectivity with Frontal Basal Ganglia Networks.Journal of cognitive neuroscience · 2021Article
- Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit.Neurobiology of learning and memory · 2020Review
- Retrosplenial cortex damage produces retrograde and anterograde context amnesia using strong fear conditioning procedures.Behavioural brain research · 2019Article
- The retrosplenial cortical role in encoding behaviorally significant cues.Behavioral neuroscience · 2018Review
- A functional circuit for the retrieval of remote cued fear memory.Behavioral neuroscience · 2018Article
- Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex.PLoS computational biology · 2018Article
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Authors and funding
4 authors.
Funding
Abstract
The retrosplenial cortex (RSP) and postrhinal cortex (POR) are heavily interconnected with medial temporal lobe structures involved in learning and memory. Previous studies indicate that RSP and POR are necessary for contextual fear conditioning, but it remains unclear whether these regions contribute individually or instead work together as a functional circuit to modulate learning and/or memory. In Experiment 1, learning-related neuronal activity was assessed in RSP from home cage, shock-only, context-only, or fear-conditioned rats using real-time PCR and immunohistochemical methods to quantify immediate-early gene expression. A significant increase in activity-regulated cytoskeleton-associated protein (Arc) mRNA and Arc and c-Fos protein expression was detected in RSP from fear-conditioned rats compared with all other groups. In Experiment 2, retrograde tracing combined with immunohistochemistry revealed that, compared with controls, a significant proportion of cells projecting from RSP to POR were immunopositive for c-Fos in fear-conditioned rats. These results demonstrate that neurons projecting from RSP to POR are indeed active during fear conditioning. In Experiment 3, a functional disconnection paradigm was used to further examine the interaction between RSP and POR during fear conditioning. Compared with controls, rats with unilateral lesions of RSP and POR on opposite sides of the brain exhibited impaired contextual fear memory, whereas rats with unilateral lesions in the same hemisphere displayed intermediate levels of freezing compared with controls and rats with contralateral lesions. Collectively, these results are the first to show that RSP and POR function as a cortical network necessary for contextual fear learning and memory.
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