Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Corticostriatal connectivity underlies individual differences in the balance between habitual and goal-directed action control.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Common and disorder-specific aberrant activation during reward and loss processing in major depressive disorder and addiction: a meta-analysis of fMRI studies.Molecular psychiatry · 2026Pooled it
- Effects of LSD, DMT and psilocybin on cognitive and psychological functions: A systematic review of the literature.Journal of psychopharmacology (Oxford, England) · 2026Pooled it
- Bad habits-good goals? Meta-analysis and translation of the habit construct to alcoholism.Translational psychiatry · 2024Pooled it
- Keeping the promise: a critique of the current state of microdosing research.Frontiers in psychiatry · 2024Pooled it
- Addiction history moderates the effect of prefrontal 10-Hz transcranial alternating current stimulation on habitual action selection.Journal of neurophysiology · 2021Trial
- Appetitive Pavlovian-to-Instrumental Transfer in Participants with Normal-Weight and Obesity.Nutrients · 2019Trial
- Shifting the balance between goals and habits: Five failures in experimental habit induction.Journal of experimental psychology. General · 2018Trial
- Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior.Scientific reports · 2018Trial
- Trial
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Unilateral Chewing Frequency and Self-Reported Mastication Satisfaction: A Cross-Sectional Study.Journal of oral rehabilitation · 2026Article
- Adaptive integration of model-based and model-free strategies in human reinforcement learning of reachable space.bioRxiv : the preprint server for biology · 2026Article
- Article
- Reinforcement Learning and Decision Making in Anorexia Nervosa.Current psychiatry reports · 2025Review
- Dissociable habits of response preparation versus response initiation.Nature human behaviour · 2025Article
- Left Ventral Caudate Functional Connectivity Mediates the Relationship Between Habitual Responding and Alcohol Use.The European journal of neuroscience · 2025Article
- Obsessive‒compulsive symptoms and associated factors among people with schizophrenia attending services at referral hospitals in Eastern Ethiopia.BMC psychiatry · 2025Article
- Maturation of striatal dopamine supports the development of habitual behavior through adolescence.bioRxiv : the preprint server for biology · 2025Article
- Localization and connections of the tail of caudate and caudal putamen in mouse brain.Frontiers in neural circuits · 2025Article
- Individualized targeting of the posterior parietal cortex with intermittent theta burst stimulation in anorexia nervosa: a randomized, double-blind, sham-controlled protocol.Frontiers in neuroscience · 2025Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Why are some individuals more susceptible to the formation of inflexible habits than others? In the present study, we used diffusion tensor imaging to demonstrate that brain connectivity predicts individual differences in relative goal-directed and habitual behavioral control in humans. Specifically, vulnerability to habitual "slips of action" toward no-longer-rewarding outcomes was predicted by estimated white matter tract strength in the premotor cortex seeded from the posterior putamen (as well as by gray matter density in the posterior putamen as determined with voxel-based morphometry). In contrast, flexible goal-directed action was predicted by estimated tract strength in the ventromedial prefrontal cortex seeded from the caudate. These findings suggest that integrity of dissociable corticostriatal pathways underlies individual differences in action control in the healthy population, which may ultimately mediate vulnerability to impulse control disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.