ArticleJournal of neurophysiology2012
Cross inhibition from ON to OFF pathway improves the efficiency of contrast encoding in the mammalian retina.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Mechanisms Underlying Myopia Progression from Visual Signaling to Metabolic Remodeling in Retina.JMA journal · 2025Review
- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
- Article
- The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022Review
- Artificial Visual Information Produced by Retinal Prostheses.Frontiers in cellular neuroscience · 2022Review
- Glycine Release Is Potentiated by cAMP via EPAC2 and CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- From Receptive to Perceptive Fields: Size-Dependent Asymmetries in Both Negative Afterimages and Subcortical On and Off Post-Stimulus Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress.Frontiers in cellular neuroscience · 2020Article
- Decreased expression of gap junction delta-2 (GJD2) messenger RNA and connexin 36 protein in form-deprivation myopia of guinea pigs.Chinese medical journal · 2019Article
- Selective synaptic connections in the retinal pathway for night vision.The Journal of comparative neurology · 2019Article
- Synaptic Transfer between Rod and Cone Pathways Mediated by AII Amacrine Cells in the Mouse Retina.Current biology : CB · 2018Article
- Firing-rate based network modeling of the dLGN circuit: Effects of cortical feedback on spatiotemporal response properties of relay cells.PLoS computational biology · 2018Article
- Asymmetries of Dark and Bright Negative Afterimages Are Paralleled by Subcortical ON and OFF Poststimulus Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Mammalian Retinal Ganglion Cell Implements a Neuronal Computation That Maximizes the SNR of Its Postsynaptic Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Synaptic Vesicle Exocytosis at the Dendritic Lobules of an Inhibitory Interneuron in the Mammalian Retina.Neuron · 2015Article
- Genetic disruption of the On visual pathway affects cortical orientation selectivity and contrast sensitivity in mice.Journal of neurophysiology · 2014Article
- Retinal connectomics: towards complete, accurate networks.Progress in retinal and eye research · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The retina is divided into parallel and mostly independent ON and OFF pathways, but the ON pathway "cross" inhibits the OFF pathway. Cross inhibition was thought to improve signal processing by the OFF pathway, but its effect on contrast encoding had not been tested experimentally. To quantify the effect of cross inhibition on the encoding of contrast, we presented a dark flash to an in vitro preparation of the mammalian retina. We then recorded excitatory currents, inhibitory currents, membrane voltages, and spikes from OFF α-ganglion cells. The recordings were subjected to an ideal observer analysis that used Bayesian methods to determine how accurately the recordings detected the dark flash. We found that cross inhibition increases the detection accuracy of currents and membrane voltages. Yet these improvements in encoding do not fully reach the spike train, because cross inhibition also hyperpolarizes the OFF α-cell below spike threshold, preventing small signals in the membrane voltages at low contrast from reaching the spike train. The ultimate effect of cross inhibition is to increase the accuracy with which the spike train detects moderate contrast, but reduce the accuracy with which it detects low contrast. In apparent compensation for the loss of accuracy at low contrast, cross inhibition, by hyperpolarizing the OFF α-cell, reduces the number of spikes required to detect the dark flash and thereby increases encoding efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.