ArticleJournal of neurophysiology2012
Cortical stimulation causes long-term changes in H-reflexes and spinal motoneuron GABA receptors.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Electrophysiological evidence of Hebbian plasticity in awake adult rats.Journal of neurophysiology · 2025Article
- Motor learning changes the axon initial segment of the spinal motoneuron.The Journal of physiology · 2024Article
- Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation.Scientific data · 2021Article
- H-reflex conditioning during locomotion in people with spinal cord injury.The Journal of physiology · 2021Article
- Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2019Article
- Operant conditioning of the tibialis anterior motor evoked potential in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2018Article
- Chemogenetic Enhancement of Axon Regeneration Following Peripheral Nerve Injury in the SLICK-A Mouse.Brain sciences · 2018Article
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- Motor cortex electrical stimulation augments sprouting of the corticospinal tract and promotes recovery of motor function.Frontiers in integrative neuroscience · 2014Review
- Corticospinal excitability is enhanced after visuomotor adaptation and depends on learning rather than performance or error.Journal of neurophysiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The cortex gradually modifies the spinal cord during development, throughout later life, and in response to trauma or disease. The mechanisms of this essential function are not well understood. In this study, weak electrical stimulation of rat sensorimotor cortex increased the soleus H-reflex, increased the numbers and sizes of GABAergic spinal interneurons and GABAergic terminals on soleus motoneurons, and decreased GABA(A) and GABA(B) receptor labeling in these motoneurons. Several months after the stimulation ended the interneuron and terminal increases had disappeared, but the H-reflex increase and the receptor decreases remained. The changes in GABAergic terminals and GABA(B) receptors accurately predicted the changes in H-reflex size. The results reveal a new long-term dimension to cortical-spinal interactions and raise new therapeutic possibilities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.