ArticleNucleic acids research2012
Promoter propagation in prokaryotes.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A hidden intrinsic ability of bicistronic expression based on a novel translation reinitiation mechanism in yeast.Nucleic acids research · 2025Article
- Mobilome impacts on physiology in the widely used non-toxic mutant Microcystis aeruginosa PCC 7806 ΔmcyB and toxic wildtype.BMC genomics · 2024Article
- Rapid functional activation of horizontally transferred eukaryotic intron-containing genes in the bacterial recipient.Nucleic acids research · 2024Article
- Tandem gene duplication selected by activation of horizontally transferred gene in bacteria.Applied microbiology and biotechnology · 2024Article
- Adding context to the pneumococcal core genes using bioinformatic analysis of the intergenic pangenome ofFrontiers in bioinformatics · 2023Article
- From a large-scale genomic analysis of insertion sequences to insights into their regulatory roles in prokaryotes.BMC genomics · 2022Article
- How sequence populations persist inside bacterial genomes.Genetics · 2021Article
- Flexibility and Adaptability of Quorum Sensing in Nature.Trends in microbiology · 2020Review
- Rapid functional activation of a horizontally transferred eukaryotic gene in a bacterial genome in the absence of selection.Nucleic acids research · 2019Article
- Random sequences rapidly evolve into de novo promoters.Nature communications · 2018Article
- Metagenomics and Bioinformatics in Microbial Ecology: Current Status and Beyond.Microbes and environments · 2016Review
- Article
- Trichodesmium genome maintains abundant, widespread noncoding DNA in situ, despite oligotrophic lifestyle.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Transfer of noncoding DNA drives regulatory rewiring in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Horizontal transfer beyond genes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Promoter reuse in prokaryotes.Mobile genetic elements · 2012Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional activation or 'rewiring' of silent genes is an important, yet poorly understood, phenomenon in prokaryotic genomes. Anecdotal evidence coming from experimental evolution studies in bacterial systems has shown the promptness of adaptation upon appropriate selective pressure. In many cases, a partial or complete promoter is mobilized to silent genes from elsewhere in the genome. We term hereafter such recruited regulatory sequences as Putative Mobile Promoters (PMPs) and we hypothesize they have a large impact on rapid adaptation of novel or cryptic functions. Querying all publicly available prokaryotic genomes (1362) uncovered >4000 families of highly conserved PMPs (50 to 100 long with ≥80% nt identity) in 1043 genomes from 424 different genera. The genomes with the largest number of PMP families are Anabaena variabilis (28 families), Geobacter uraniireducens (27 families) and Cyanothece PCC7424 (25 families). Family size varied from 2 to 93 homologous promoters (in Desulfurivibrio alkaliphilus). Some PMPs are present in particular species, but some are conserved across distant genera. The identified PMPs represent a conservative dataset of very recent or conserved events of mobilization of non-coding DNA and thus they constitute evidence of an extensive reservoir of recyclable regulatory sequences for rapid transcriptional rewiring.
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