ArticleThe Journal of clinical endocrinology and metabolism2012
Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity.
Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.The Journal of nutrition · 2020Trial
- Effects of statin therapy and exercise on postprandial triglycerides in overweight individuals with hypercholesterolaemia.British journal of clinical pharmacology · 2020Trial
- Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis.The Journal of clinical endocrinology and metabolism · 2016Trial
- Estimates of insulin sensitivity from the intravenous-glucose-modified-clamp test depend on suppression of lipolysis in type 2 diabetes: a randomised controlled trial.Diabetologia · 2014Trial
- Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans.Physiological reviews · 2025Review
- Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets.Cardiovascular research · 2023Review
- Metabolic changes in aging humans: current evidence and therapeutic strategies.The Journal of clinical investigation · 2022Review
- Unexpected Postprandial Energy Expenditure and Fuel Oxidation Responses to Meals with Different Macronutrient Compositions.The Journal of nutrition · 2022Article
- Mechanism of Action of Shenerjiangzhi Formulation on Hyperlipidemia Induced by Consumption of a High-Fat Diet in Rats Using Network Pharmacology and Analyses of the Gut Microbiota.Frontiers in pharmacology · 2022Article
- Adipocyte Insulin Resistance in PCOS: Relationship With GLUT-4 Expression and Whole-Body Glucose Disposal and β-Cell Function.The Journal of clinical endocrinology and metabolism · 2020Article
- Errors in measuring plasma free fatty acid concentrations with a popular enzymatic colorimetric kit.Clinical biochemistry · 2019Article
- Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse.Biology of reproduction · 2018Article
- Iron Status and Metabolic Syndrome in Patients with Non-Alcoholic Fatty Liver Disease.Middle East journal of digestive diseases · 2016Article
- Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity.The Journal of clinical endocrinology and metabolism · 2015Article
- Insulin resistance in rheumatoid arthritis: disease-related indicators and associations with the presence and progression of subclinical atherosclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- The expression of inflammatory cytokines on the aorta endothelia are up-regulated in pinealectomized rats.Inflammation · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextA central/visceral fat distribution and excess free fatty acid (FFA) availability are associated with dyslipidemia and insulin resistance. However, these two characteristics often coexist, making it difficult to detect the independent contributions of each. Whether FFA suppression is more closely linked to metabolic abnormalities is not clear.
objectiveThe aim of the study was to examine the relationship between FFA suppression, body fat distribution, and fitness as contributors toward insulin resistance and hypertriglyceridemia.
designWe measured systemic palmitate turnover using an iv infusion of [9,10-(3)H]palmitate; upper body sc adipose tissue (UBSQ) and visceral adipose tissue (VAT) with dual-energy x-ray absorptiometry and a single-slice abdominal computed tomography scan; fitness with a graded exercise treadmill test; and insulin sensitivity with both the iv glucose tolerance test (IVGTT) (SI(IVGTT)) and mixed meal tolerance test (SI(Meal)).
settingThe study was conducted at a General Clinical Research Center.
participantsBaseline data were obtained from 140 elderly adults (age, 60-88 yr; 83 males) and 60 young adults (age, 18-31 yr; 31 males) who participated in a previously published trial assessing the effects of 2-yr supplementation of dehydroepiandrosterone or testosterone on body composition, glucose metabolism, and bone density.
interventionsThere were no interventions.
main outcome measuresWe measured fasting plasma triglyceride (TG) concentrations, SI(IVGTT), and SI(Meal).
resultsUsing multivariate regression analysis, the strongest combined predictors of TG concentrations were VAT, postmeal nadir FFA concentrations, sex, and age. The best predictors of SI(IVGTT) were IVGTT nadir palmitate concentration, VAT, UBSQ fat, fitness, and age, whereas the best predictors of SI(Meal) were meal nadir palmitate concentration, UBSQ fat, fitness, and sex.
conclusionsFFA suppression is associated with both fasting TG concentrations and insulin sensitivity, independent of measures of adiposity.
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Registered trials
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