ArticleCerebral cortex (New York, N.Y. : 1991)2013
Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02170142 (The Major Goal of This Project is to Characterize the Structural and Functional Development of Cortical Plate and White Matter of the Human Neonatal Brain From the Equivalent 30 Gestational Weeks to 45 Gestational Weeks.), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Major Goal of This Project is to Characterize the Structural and Functional Development of Cortical Plate and White Matter of the Human Neonatal Brain From the Equivalent 30 Gestational Weeks to 45 Gestational Weeks.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Novel imaging techniques to study postmortem human fetal anatomy: a systematic review on microfocus-CT and ultra-high-field MRI.European radiology · 2020Pooled it
- Effects of antidepressant medications on brain tissue microstructure in persistent depressive disorder across two randomized controlled trials.NeuroImage. Clinical · 2026Trial
- Article
- Imaging of Embryonic and Fetal Brain Development Using MRI Microscopy: Achieving High Spatial Resolution.Medical sciences (Basel, Switzerland) · 2026Review
- Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex.Nature communications · 2026Article
- Diffusion-MRI-Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A computational model of radial scaffolds in the human fetal brain based on MRI.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Regional Changes in the Fetal Telencephalic Wall Diffusion Metrics Across Late Second and Third Trimesters.Human brain mapping · 2025Article
- Ex vivo Magnetic Resonance Imaging of the Human Fetal Brain.Developmental neuroscience · 2025Review
- Molecular signatures of cortical expansion in the human foetal brain.Nature communications · 2024Article
- Machine-learning based prediction of future outcome using multimodal MRI during early childhood.Seminars in fetal & neonatal medicine · 2024Review
- Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network.eLife · 2023Article
- microRNA Biology on Brain Development and Neuroimaging Approach.Brain sciences · 2022Review
- Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors.Neuron · 2022Review
- Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age.NeuroImage · 2021Article
- Association between Quantitative MR Markers of Cortical Evolving Organization and Gene Expression during Human Prenatal Brain Development.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.Magnetic resonance in medicine · 2021Article
- Early development of human ganglionic eminences assessedMedicine and pharmacy reports · 2021Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
As a prominent component of the human fetal brain, the structure of the cerebral wall is characterized by its laminar organization which includes the radial glial scaffold during fetal development. Diffusion tensor imaging (DTI) is useful to quantitatively delineate the microstructure of the developing brain and to clearly identify transient fetal layers in the cerebral wall. In our study, the spatio-temporal microstructural changes in the developing human fetal cerebral wall were quantitatively characterized with high-resolution DTI data of postmortem fetal brains from 13 to 21 gestational weeks. Eleven regions of interest for each layer in the entire cerebral wall were included. Distinctive time courses of microstructural changes were revealed for 11 regions of the neocortical plate. A histological analysis was also integrated to elucidate the relationship between DTI fractional anisotropy (FA) and histology. High FA values correlated with organized radial architecture in histological image. Expression levels of 17565 genes were quantified for each of 11 regions of human fetal neocortex from 13 to 21 gestational weeks to identify transcripts showing significant correlation with FA change. These correlations suggest that the heterogeneous and regionally specific microstructural changes of the human neocortex are related to different gene expression patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.