ArticleDiabetes care2013
Novel risk factors and the prediction of type 2 diabetes in the Atherosclerosis Risk in Communities (ARIC) study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study.Endocrinology, diabetes & metabolism · 2025Article
- Clinical and Radiological Fusion: A New Frontier in Predicting Post-Transplant Diabetes Mellitus.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- The complement system in lipid-mediated pathologies.Frontiers in immunology · 2024Review
- Predictive model of diabetes mellitus in patients with idiopathic inflammatory myopathies.Frontiers in endocrinology · 2023Article
- Clonal hematopoiesis as a novel risk factor for type 2 diabetes mellitus in patients with hypercholesterolemia.Frontiers in public health · 2023Article
- Article
- Agreement between Type 2 Diabetes Risk Scales in a Caucasian Population: A Systematic Review and Report.Journal of clinical medicine · 2020Article
- Multiple Biomarkers Improved Prediction for the Risk of Type 2 Diabetes Mellitus in Singapore Chinese Men and Women.Diabetes & metabolism journal · 2020Article
- Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study.Medicine · 2019Observational
- A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.Genetic epidemiology · 2017Article
- Individual- and Area-Level SES in Diabetes Risk Prediction: The Multi-Ethnic Study of Atherosclerosis.American journal of preventive medicine · 2017Article
- Utility of existing diabetes risk prediction tools for young black and white adults: Evidence from the Bogalusa Heart Study.Journal of diabetes and its complications · 2017Article
- Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data.Circulation. Cardiovascular genetics · 2016Observational
- Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes.Cardiovascular diabetology · 2016Article
- Discriminatory value of alanine aminotransferase for diabetes prediction: the Insulin Resistance Atherosclerosis Study.Diabetic medicine : a journal of the British Diabetic Association · 2016Article
- Association between liver enzymes and incident type 2 diabetes in Singapore Chinese men and women.BMJ open diabetes research & care · 2016Article
- Non-traditional risk factors are important contributors to the racial disparity in diabetes risk: the atherosclerosis risk in communities study.Journal of general internal medicine · 2014Article
- Introduction to personalized medicine in diabetes mellitus.Rambam Maimonides medical journal · 2014Article
- Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.Diabetologia · 2014Article
- Insights into the genetic basis of type 2 diabetes.Journal of diabetes investigation · 2013Review
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe objective of this study was to determine potential added value of novel risk factors in predicting the development of type 2 diabetes beyond that provided by standard clinical risk factors. RESEARCH DESIGN AND
methodsThe Atherosclerosis Risk in Communities (ARIC) Study is a population-based prospective cohort study in four U.S. communities. Novel risk factors were either measured in the full cohort or in a case-control sample nested within the cohort. We started with a basic prediction model, previously validated in ARIC, and evaluated 35 novel risk factors by adding them independently to the basic model. The area under the curve (AUC), net reclassification index (NRI), and integrated discrimination index (IDI) were calculated to determine if each of the novel risk factors improved risk prediction.
resultsThere were 1,457 incident cases of diabetes with a mean of >7.6 years of follow-up among 12,277 participants at risk. None of the novel risk factors significantly improved the AUC. Forced expiratory volume in 1 s was the only novel risk factor that resulted in a significant NRI (0.54%; 95% CI: 0.33-0.86%). Adiponectin, leptin, γ-glutamyl transferase, ferritin, intercellular adhesion molecule 1, complement C3, white blood cell count, albumin, activated partial thromboplastin time, factor VIII, magnesium, hip circumference, heart rate, and a genetic risk score each significantly improved the IDI, but net changes were small.
conclusionsEvaluation of a large panel of novel risk factors for type 2 diabetes indicated only small improvements in risk prediction, which are unlikely to meaningfully alter clinical risk reclassification or discrimination strategies.
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