ArticleAnatomical record (Hoboken, N.J. : 2007)2012
Transgenic analysis of signaling pathways required for Xenopus tadpole spinal cord and muscle regeneration.
Article in Anatomical record (Hoboken, N.J. : 2007), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Tail Tales: What We Have Learned About Regeneration from Xenopus Laevis Tadpoles.International journal of molecular sciences · 2024Review
- Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax.Cell & bioscience · 2023Article
- Injury-induced Erk1/2 signaling tissue-specifically interacts with CaCell calcium · 2022Article
- Unique advantages of zebrafish larvae as a model for spinal cord regeneration.Frontiers in molecular neuroscience · 2022Review
- Article
- JAK-STAT pathway activation in response to spinal cord injury in regenerative and non-regenerative stages ofRegeneration (Oxford, England) · 2017Article
- Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS.The International journal of developmental biology · 2015Article
- Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in Xenopus laevis embryos.The International journal of developmental biology · 2015Article
- Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury.Experimental neurology · 2014Review
- Notochord-derived hedgehog is essential for tail regeneration in Xenopus tadpole.BMC developmental biology · 2014Article
- Studying mechanisms of regeneration in amphibian and reptilian vertebrate models.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Xenopus tadpole has the capacity fully to regenerate its tail after amputation. Previously, we have established that this regeneration process requires the operation of several signaling pathways including the bone morphogenic protein, Wnt, and Fgf pathways. Here, we have addressed the signaling requirements for spinal cord and muscle regeneration in a tissue-specific manner. Two methods were used namely grafts of transgenic spinal cord to a wild type host, and the use of the Tet-on conditional transgenic system to express inhibitors in the individual tissues. For the grafting experiments, the tail was amputated through the graft, which contained a temperature inducible inhibitor of the Wnt-β-catenin pathway. For the Tet-on experiments, treatment with doxycycline was used to induce cell autonomous inhibitors of the Wnt-β-catenin or the Fgf pathway in either spinal cord or muscle. The results show that both spinal cord and muscle regeneration depend on both the Wnt-β-catenin and the Fgf pathways. This experimental design also enables us to observe the effect of inhibition of regeneration of one tissue on the regeneration of the others. Regardless of the method of inhibition, we find that reduction of spinal cord regeneration reduces regeneration of other parts of the tail, including the myotomal muscles. In contrast, reduction of muscle regeneration has no effect on the regeneration of the spinal cord. In common with other regeneration systems, this indicates that soluble factors from the spinal cord are needed to promote the regeneration of the other tissues in the tail.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.