ReviewChembiochem : a European journal of chemical biology2012
Chemical biology for understanding matrix metalloproteinase function.
Review in Chembiochem : a European journal of chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- FRET Sensor-Modified Synthetic Hydrogels for Real-Time Monitoring of Cell-Derived Matrix Metalloproteinase Activity using Fluorescence Lifetime Imaging.Advanced functional materials · 2024Article
- MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging.Biomaterials science · 2020Article
- Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities.Current rheumatology reports · 2020Review
- DNA methyltransferase genes polymorphisms are associated with primary knee osteoarthritis: a matched case-control study.Rheumatology international · 2020Observational
- Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer.Organic & biomolecular chemistry · 2018Article
- DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications.The open rheumatology journal · 2018Review
- Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.Scientific reports · 2017Article
- Effect of the interaction between MiR-200b-3p and DNMT3A on cartilage cells of osteoarthritis patients.Journal of cellular and molecular medicine · 2017Article
- Current Therapeutic Approach to Hypertrophic Scars.Frontiers in medicine · 2017Review
- Collapsed Reticular Network and its Possible Mechanism during the Initiation and/or Progression of Hepatic Fibrosis.Scientific reports · 2016Article
- Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring.Advances in wound care · 2015Review
- Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo.Bioorganic & medicinal chemistry letters · 2014Article
- Mmp-9 responsive PEG cleavable nanovesicles for efficient delivery of chemotherapeutics to pancreatic cancer.Molecular pharmaceutics · 2014Article
- Future nanomedicine for the diagnosis and treatment of osteoarthritis.Nanomedicine (London, England) · 2014Review
- Exendin-4 ameliorates oxidized-LDL-induced inhibition of macrophage migration in vitro via the NF-κB pathway.Acta pharmacologica Sinica · 2014Article
- Architecture and function of metallopeptidase catalytic domains.Protein science : a publication of the Protein Society · 2014Review
- The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.The Journal of biological chemistry · 2014Article
- Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity.Journal of the American Chemical Society · 2013Article
- TAGLN suppresses proliferation and invasion, and induces apoptosis of colorectal carcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Planarians as a model to assess in vivo the role of matrix metalloproteinase genes during homeostasis and regeneration.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The matrix metalloproteinase (MMP) family has long been associated with normal physiological processes such as embryonic implantation, tissue remodeling, organ development, and wound healing, as well as multiple aspects of cancer initiation and progression, osteoarthritis, inflammatory and vascular diseases, and neurodegenerative diseases. The development of chemically designed MMP probes has advanced our understanding of the roles of MMPs in disease in addition to shedding considerable light on the mechanisms of MMP action. The first generation of protease-activated agents has demonstrated proof of principle as well as providing impetus for in vivo applications. One common problem has been a lack of agent stability at nontargeted tissues and organs due to activation by multiple proteases. The present review considers how chemical biology has impacted the progress made in understanding the roles of MMPs in disease and the basic mechanisms of MMP action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.