ArticleAmerican journal of physiology. Renal physiology2012
Use of ultrasound to assess renal reperfusion and P-selectin expression following unilateral renal ischemia.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 23 citations in OpenAlex.
- Quantification of Kidney Inflammation Using Nanobubble-mediated Contrast Enhanced Ultrasound.Nanotheranostics · 2026Article
- Targeted Polymer-Peptide Conjugates for E-Selectin Blockade in Renal Injury.Pharmaceutics · 2025Article
- Ultrasound Molecular Imaging Enhances High-Intensity Focused Ultrasound Ablation on Liver Cancer With B7-H3-Targeted Microbubbles.Cancer medicine · 2024Article
- Non-invasive molecular imaging of kidney diseases.Nature reviews. Nephrology · 2021Review
- Ultrasound measurement of change in kidney volume is a sensitive indicator of severity of renal parenchymal injury.American journal of physiology. Renal physiology · 2020Article
- Lack of Connexins 40 and 45 Reduces Local and Conducted Vasoconstrictor Responses in the Murine Afferent Arterioles.Frontiers in physiology · 2020Article
- A rat model of acute kidney injury through systemic hypoperfusion evaluated by micro-US, color and PW-Doppler.La Radiologia medica · 2019Article
- Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury.American journal of physiology. Renal physiology · 2019Article
- ETPhysiological reports · 2018Article
- Endothelial colony-forming cells and pro-angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury.Acta physiologica (Oxford, England) · 2018Review
- Long-Term Administration of Angiotensin (1-7) toOxidative medicine and cellular longevity · 2018Article
- New Ultrasound Techniques Promise Further Advances in AKI and CKD.Journal of the American Society of Nephrology : JASN · 2017Review
- Vasa recta pericyte density is negatively associated with vascular congestion in the renal medulla following ischemia reperfusion in rats.American journal of physiology. Renal physiology · 2017Article
- Endothelial colony-forming cells ameliorate endothelial dysfunction via secreted factors following ischemia-reperfusion injury.American journal of physiology. Renal physiology · 2017Article
- Lack of an apparent role for endothelin-1 in the prolonged reduction in renal perfusion following severe unilateral ischemia-reperfusion injury in the mouse.Physiological reports · 2016Article
- Molecular Ultrasound Imaging of Tissue Inflammation Using an Animal Model of Acute Kidney Injury.Molecular imaging and biology · 2015Article
- Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.American journal of physiology. Renal physiology · 2015Article
- Effects of ischemic preconditioning on the systemic and renal hemodynamic changes in renal ischemia reperfusion injury.International journal of clinical and experimental pathology · 2015Article
- Taking a sound approach to acute kidney injury.American journal of physiology. Renal physiology · 2012Article
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3 authors at 1 institution in 1 country.
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Abstract
Renal ischemia-reperfusion injury is a major cause of acute kidney injury that carries a high mortality rate and increases the risk of later development of hypertension and chronic kidney disease. Although mouse models have contributed much to our understanding of the mechanisms involved, studying aspects of the injury process in vivo remains technically challenging. This study validates the use of noninvasive ultrasound imaging to assess both renal perfusion and vascular adhesion molecule expression following 1-h unilateral renal ischemia in male and female mice. Pulsed-wave Doppler measurements of renal arterial blood velocity revealed renal perfusion recoveries of 56 ± 9% in male and 69 ± 10% in female mice 1 h after the commencing of reperfusion, which is similar to what we have previously published using conventional invasive methodology. At 24 h postischemia, renal perfusion was 40 ± 8% in male and 46 ± 7% in female mice, representing a further significant reduction of perfusion (P(Time) < 0.001). Using ultrasound imaging of a P-selectin-targeted contrast agent, a significant increase in vascular P-selectin protein expression was observed after 1-h reperfusion in the cortex of the postischemic compared with contralateral kidney in both male and female mice (18 ± 5 vs. 3 ± 3 intensity units in male and 30 ± 6 vs. 0 ± 4 in female mice, P(Ischemia) < 0.01). An approximately sixfold increase in P-selectin mRNA was observed ex vivo in the renal vasculature of male and female mice at this time point (P < 0.01). In conclusion, ultrasound represents an effective and noninvasive method for the measurement of both renal perfusion and vascular adhesion molecule expression in mice.
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