ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Remodeling of intrinsic cardiac neurons: effects of β-adrenergic receptor blockade in guinea pig models of chronic heart disease.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Autonomic regulation therapy to enhance myocardial function in heart failure patients: the ANTHEM-HFpEF study.ESC heart failure · 2018Trial
- Comparative specialization of intrinsic cardiac neurons in humans, mice and pigs.The Journal of physiology · 2025Article
- Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats.Autonomic neuroscience : basic & clinical · 2024Article
- Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease.Frontiers in physiology · 2023Review
- Influence of cardiac nerve status on cardiovascular regulation and cardioprotection.World journal of cardiology · 2017Review
- Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction.PloS one · 2017Article
- Vagal stimulation targets select populations of intrinsic cardiac neurons to control neurally induced atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Vagus nerve stimulation mitigates intrinsic cardiac neuronal remodeling and cardiac hypertrophy induced by chronic pressure overload in guinea pig.American journal of physiology. Heart and circulatory physiology · 2016Article
- Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction.American journal of physiology. Heart and circulatory physiology · 2015Article
- Angiotensin receptors alter myocardial infarction-induced remodeling of the guinea pig cardiac plexus.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Cardiac innervation and sudden cardiac death.Circulation research · 2015Review
- Dynamic remodeling of the guinea pig intrinsic cardiac plexus induced by chronic myocardial infarction.Autonomic neuroscience : basic & clinical · 2014Article
- Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function.The Journal of physiology · 2013Article
- The dopamine D3 receptor knockout mouse mimics aging-related changes in autonomic function and cardiac fibrosis.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic heart disease induces remodeling of cardiac tissue and associated neuronal components. Treatment of chronic heart disease often involves pharmacological blockade of adrenergic receptors. This study examined the specific changes in neuronal sensitivity of guinea pig intrinsic cardiac neurons to autonomic modulators in animals with chronic cardiac disease, in the presence or absence of adrenergic blockage. Myocardial infarction (MI) was produced by ligature of the coronary artery and associated vein on the dorsal surface of the heart. Pressure overload (PO) was induced by a banding of the descending dorsal aorta (∼20% constriction). Animals were allowed to recover for 2 wk and then implanted with an osmotic pump (Alzet) containing either timolol (2 mg·kg(-1)·day(-1)) or vehicle, for a total of 6-7 wk of drug treatment. At termination, intracellular recordings from individual neurons in whole mounts of the cardiac plexus were used to assess changes in physiological responses. Timolol treatment did not inhibit the increased sensitivity to norepinephrine seen in both MI and PO animals, but it did inhibit the stimulatory effects of angiotensin II on the norepinephrine-induced increases in neuronal excitability. Timolol treatment also inhibited the increase in synaptically evoked action potentials observed in PO animals with stimulation of fiber tract bundles. These results demonstrate that β-adrenergic blockade can inhibit specific aspects of remodeling within the intrinsic cardiac plexus. In addition, this effect was preferentially observed with active cardiac disease states, indicating that the β-receptors were more influential on remodeling during dynamic disease progression.
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Registered trials
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