Evidence map›Paper›PMID 22932777›Full record

Trial reportPsychopharmacology2013

Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial.

Lai Kuan Lee, Suzana Shahar, Ai-Vyrn Chin, Noor Aini Mohd Yusoff

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02778581 (Randomized, Double Blind, Placebo Controlled Prospective Study, to Evaluate the Effect of a Vegetal Oil in the Disease's Natural Evolution in Patients Diagnosed With Cognitive Impairment or Mild to Moderate Alzheimer Disease.), which is not on this map. Cited by 93 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 13 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02778581 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Randomized, Double Blind, Placebo Controlled Prospective Study, to Evaluate the Effect of a Vegetal Oil in the Disease's Natural Evolution in Patients Diagnosed With Cognitive Impairment or Mild to Moderate Alzheimer Disease.

TypeinterventionalSponsorTeam Foods Colombia S.A.Ran2016 to 2017Enrolled110ConditionsCognitive Impairments, Alzheimer DiseaseArmsLipidic Blend 1, Lipidic Blend 2, Placebo
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 13 syntheses or guidelines pooled it, 208 citations in OpenAlex.

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  12. Recommendations on screening for cognitive impairment in older adults.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016
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  15. A standardized combination ofFrontiers in nutrition · 2025
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lai Kuan LeeNutrition Science Program, School of Health Care Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Suzana Shahar
Ai-Vyrn Chin
Noor Aini Mohd Yusoff
National University of Malaysia · MYUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleEpidemiological studies have suggested a beneficial effect of fish oil supplementation in halting the initial progression of Alzheimer's disease. However, it remains unclear whether fish oil affects cognitive function in older people with mild cognitive impairment (MCI).

objectivesThis study investigated the effects of fish oil supplementation on cognitive function in elderly person with MCI.

methodsThis was a 12-month, randomised, double-blind, placebo-controlled study using fish oil supplementation with concentrated docosahexaenoic acid (DHA). Thirty six low-socioeconomic-status elderly subjects with MCI were randomly assigned to receive either concentrated DHA fish oil (n = 18) or placebo (n = 18) capsules. The changes of memory, psychomotor speed, executive function and attention, and visual-constructive skills were assessed using cognitive tests. Secondary outcomes were safety and tolerability of the DHA concentrate.

resultsThe fish oil group showed significant improvement in short-term and working memory (F = 9.890; ηp (2) = 0.254; p < 0.0001), immediate verbal memory (F = 3.715; ηp (2) = 0.114; p < 0.05) and delayed recall capability (F = 3.986; ηp (2) = 0.121; p < 0.05). The 12-month change in memory (p < 0.01) was significantly better in the fish oil group. Fish oil consumption was well tolerated, and the side effects were minimal and self-limiting.

conclusionsThis study suggested the potential role of fish oil to improve memory function in MCI subjects. Studies with larger sample sizes, longer intervention periods, different fish oil dosages and genetic determinations should be investigated before definite recommendations can be made.

Indexed as

AgedAnalysis of VarianceCognitionCognition DisordersDietary SupplementsDocosahexaenoic AcidsDouble-Blind MethodFemaleFish OilsHumansMaleMemory, Short-TermMiddle AgedPsychomotor PerformanceSeverity of Illness IndexSocioeconomic FactorsDocosahexaenoic AcidsFish Oils

Identifiers

PMID22932777
OpenAlexW2075373003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.