ArticleThe Plant cell2012
A missense mutation in the glucosamine-6-phosphate N-acetyltransferase-encoding gene causes temperature-dependent growth defects and ectopic lignin deposition in Arabidopsis.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular mapping and candidate gene identification of two major quantitative trait loci associated with silique length in oilseed rape (Molecular breeding : new strategies in plant improvement · 2024Article
- Hexosamine biosynthesis and related pathways, protein N-glycosylation and O-GlcNAcylation: their interconnection and role in plants.Frontiers in plant science · 2024Review
- Chemoproteomic profiling of O-GlcNAcylated proteins and identification of O-GlcNAc transferases in rice.Plant biotechnology journal · 2023Article
- THESEUS1 is involved in tunicamycin-induced root growth inhibition, ectopic lignin deposition, and cell wall damage-induced unfolded protein response.Plant biotechnology (Tokyo, Japan) · 2022Article
- Interference of ArabidopsisFrontiers in plant science · 2022Article
- Article
- UDP-Frontiers in plant science · 2021Article
- Image analysis of stress-induced lignin deposition inPlant biotechnology (Tokyo, Japan) · 2020Article
- Article
- The Temperature-Dependent Retention of Introns inInternational journal of molecular sciences · 2019Article
- Deficiency of AtGFAT1 activity impairs growth, pollen germination and tolerance to tunicamycin in Arabidopsis.Journal of experimental botany · 2019Article
- Article
- Allocation of Heme Is Differentially Regulated by Ferrochelatase Isoforms in Arabidopsis Cells.Frontiers in plant science · 2016Article
- Transcriptome changes in apple peel tissues during CO2 injury symptom development under controlled atmosphere storage regimens.Horticulture research · 2015Article
- Accumulation of N-acetylglucosamine oligomers in the plant cell wall affects plant architecture in a dose-dependent and conditional manner.Plant physiology · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
To study the regulatory mechanisms underlying lignin biosynthesis, we isolated and characterized lignescens (lig), a previously undescribed temperature-sensitive mutant of Arabidopsis thaliana that exhibits ectopic lignin deposition and growth defects under high-temperature conditions. The lig mutation was identified as a single base transition in GNA1 encoding glucosamine-6-phosphate N-acetyltransferase (GNA), a critical enzyme of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis. lig harbors a glycine-to-serine substitution at residue 68 (G68S) of GNA1. Enzyme activity assays of the mutant protein (GNA1(G68S)) showed its thermolability relative to the wild-type protein. The lig mutant exposed to the restrictive temperature contained a significantly smaller amount of UDP-GlcNAc than did the wild type. The growth defects and ectopic lignification of lig were suppressed by the addition of UDP-GlcNAc. Since UDP-GlcNAc is an initial sugar donor of N-glycan synthesis and impaired N-glycan synthesis is known to induce the unfolded protein response (UPR), we examined possible relationships between N-glycan synthesis, UPR, and the lig phenotype. N-glycans were reduced and LUMINAL BINDING PROTEIN3, a typical UPR gene, was expressed in lig at the restrictive temperature. Furthermore, treatment with UPR-inducing reagents phenocopied the lig mutant. Our data collectively suggest that impairment of N-glycan synthesis due to a shortage of UDP-GlcNAc leads to ectopic lignin accumulation, mostly through the UPR.
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