Evidence map›Paper›PMID 22932281›Full record

Trial reportThe American journal of clinical nutrition2012

Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish.

Lucy M Browning, Celia G Walker, Adrian P Mander, Annette L West, Jackie Madden, Joanna M Gambell, Stephen Young, Laura Wang, Susan A Jebb, Philip C Calder

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02610270 (Erythrocyte Omega-3 Fatty Acid Content in Elite Athletes in Response to Omega-3 Supplementation), which is not on this map. Cited by 143 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 17 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02610270 early_phase1completednot on this mapstarted 2014, after this paper: background citation

Erythrocyte Omega-3 Fatty Acid Content in Elite Athletes in Response to Omega-3 Supplementation: A Dose-Response

TypeinterventionalSponsorCentre d'Alt RendimentRan2014 to 2015Enrolled24ConditionsHealthyArms2 Gums, 3 Gums
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 17 syntheses or guidelines pooled it, 311 citations in OpenAlex.

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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lucy M BrowningMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom.
Celia G Walker
Adrian P Mander
Annette L West
Jackie Madden
Joanna M Gambell
Stephen Young
Laura Wang
Susan A Jebb
Philip C Calder
MRC Human Nutrition Research · GB

Funding

Medical Research Council MC_U105960389Medical Research Council U1052.00.014Medical Research Council U105960389
6 · The paper itself

Abstract

backgroundEstimation of the intake of oily fish at a population level is difficult. The measurement of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in biological samples may provide a useful biomarker of intake.

objectiveWe identified the most appropriate biomarkers for the assessment of habitual oily fish intake and changes in intake by elucidating the dose- and time-dependent response of EPA and DHA incorporation into various biological samples that represent roles in fatty acid transport, function, and storage.

designThis was a double-blind, randomized, controlled intervention trial in 204 men and women that lasted 12 mo. EPA and DHA capsules were provided in a manner to reflect sporadic consumption of oily fish (ie, 1, 2, or 4 times/wk). EPA and DHA were assessed at 9 time points over 12 mo in 9 sample types (red blood cells, mononuclear cells, platelets, buccal cells, adipose tissue, plasma phosphatidylcholine, triglycerides, cholesteryl esters, and nonesterified fatty acids).

resultsA dose response (P < 0.05) was observed for EPA and DHA in all pools except for red blood cell EPA (P = 0.057). EPA and DHA measures in plasma phosphatidylcholine and platelets were best for the discrimination between different intakes (P < 0.0001). The rate of incorporation varied between sample types, with the time to maximal incorporation ranging from days (plasma phosphatidylcholine) to months (mononuclear cells) to >12 mo (adipose tissue).

conclusionsPlasma phosphatidylcholine EPA plus DHA was identified as the most suitable biomarker of acute changes in EPA and DHA intake, and platelet and mononuclear cell EPA plus DHA were the most suitable biomarkers of habitual intake.

Indexed as

DietDietary SupplementsFishesLipid MetabolismAdultAgedAnimalsBiomarkersBlood PlateletsDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFemaleHumansLeukocytes, MononuclearMaleBiomarkersDocosahexaenoic AcidsEicosapentaenoic AcidPhosphatidylcholines

Identifiers

PMID22932281
PMCPMC3441107
OpenAlexW2143659187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.